E7034

EX-527

Name: EX-527
Brand: SIGMA
Price: 740 PLN

≥98% (HPLC), SIRT1 and SIRT6 inhibitor, powder

Synonim(y):

6-Chloro-2,3,4,9-tetrahydro-1H-Carbazole-1-carboxamide

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5 MG

740,00 zł

25 MG

2310,00 zł

740,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₃H₁₃ClN₂O

Numer CAS:

49843-98-3

Masa cząsteczkowa:

248.71

UNSPSC Code:

12352200

PubChem Substance ID:

329799003

NACRES:

NA.77

MDL number:

MFCD03009471

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Nazwa produktu

EX-527, ≥98% (HPLC)

SMILES string

NC(=O)C1CCCc2c1[nH]c3ccc(Cl)cc23

InChI key

FUZYTVDVLBBXDL-UHFFFAOYSA-N

InChI

1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

Quality Level

100

Powiązane kategorie

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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Ta pozycja	L6670	SML0003	F9932
Sigma-Aldrich E7034 EX-527	Sigma-Aldrich L6670 LY266097	Sigma-Aldrich SML0003 CID755673	Sigma-Aldrich F9932 FFN511 trifluoroacetate salt hydrate
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >20 mg/mL	solubility DMSO: ≥20 mg/mL	solubility DMSO: ≥15 mg/mL	solubility DMSO: ≥20 mg/mL
color white to beige	color white to tan	color white to tan	color yellow

Application

EX-527 has been used:

in 1% dimethyl sulfoxide, 30%, polyethylene glycol-400 and 1% Tween 80 for treating C57BL/6 N mice to study its effect on intestinal morphological changes and crypt cell apoptosis
as a an inhibitor of sirtuin 1, in treating human cancer lines MCF-7 (Michigan cancer foundation-7) and HCT116 (colon cancer cell line) incubated in Dulbecco′s modified Eagle′s medium, to study its effect on mitochondrial ATP (adenosine triphosphate) production
Intracerebroventricularly infused in rat model of epileptogenesis, to access kainic acid–induced status epilepticus stimulated sirtuin 1 activity

Biochem/physiol Actions

EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive.

Potent SIRT1 and SIRT6 inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

A Rise in ATP, ROS, and Mitochondrial Content upon Glucose Withdrawal Correlates with a Dysregulated Mitochondria Turnover Mediated by the Activation of the Protein Deacetylase SIRT1

Song S and Hwang E

Cells, 8(1), 11-11 (2019)

Adipocyte differentiation is regulated by mitochondrial trifunctional protein α-subunit via sirtuin 1.

Hong-Xia Liu et al.

Experimental cell research, 357(2), 271-281 (2017-05-30)

Mitochondrial trifunctional protein α-subunit (MTPα) is involved in the fatty acid β-oxidation (FAO) pathway. Two MTPα activities, 3-hydroxyacyl-CoA dehydrogenase and long-chain hydratase, have been linked with the occurrence and development of obesity and obesity-related disorders. These activities catalyze two steps

Spinal miR-34a regulates inflammatory pain by targeting SIRT1 in complete Freund's adjuvant mice.

Shuangdong Chen et al.

Biochemical and biophysical research communications, 516(4), 1196-1203 (2019-07-13)

Sirtuin1 (SIRT1), which is regulated by microRNA-34a (miR-34a), can modulate pathophysiology processes, including nonalcoholic fatty liver disease and intestinal ischemia/reperfusion injury. We previously reported that SIRT1, an NAD+-dependent deacetylase, plays a vital role in the development of neuropathic pain. However

Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.

Ayana N Martin et al.

Journal of immunology research, 2018, 2402593-2402593 (2018-08-03)

Resistance and tolerance to infection are two universal fitness and survival strategies used by inflammation and immunity in organisms and cells to guard homeostasis. During sepsis, however, both strategies fail, and animal and human victims often die from combined innate

The protective effects of Resveratrol against radiation-induced intestinal injury

Zhang H, et al.

BMC Complementary and Alternative Medicine, 17(1), 410-410 (2017)

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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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EX-527