E4642

(±)-Epinephrine hydrochloride

≥98% (TLC), powder, adrenergic receptor agonist

• Synonim(y): (±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
• Wzór empiryczny (zapis Hilla): C₉H₁₃NO₃ · HCl
• Numer CAS: 329-63-5
• Masa cząsteczkowa: 219.67
• NACRES: NA.77
• PubChem Substance ID: 24278422
• UNSPSC Code: 12352200
• EC Number: 206-346-0
• MDL number: MFCD00050562
• Quality level: 200

Właściwości

• Nazwa produktu: (±)-Epinephrine hydrochloride,
• InChI key: ATADHKWKHYVBTJ-UHFFFAOYSA-N
• InChI: 1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
• SMILES string: OC(CNC)C1=CC=C(O)C(O)=C1.Cl
• solubility: H₂O: 50 mg/mL
• storage temp.: 2-8°C
• Quality Level: 200
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)

Opis

General description

Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system. It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors. Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.

Application

(±)-Epinephrine hydrochloride has been used:

• in the induction of renalase expression in Human renal proximal tubular epithelial cells
• in the infusion studies to test its effect on heart rate and eye temperature measurements in bull
• as a medium supplement for the stimulation of endothelial progenitor cells

Biochem/physiol Actions

Adrenergic receptor agonist.

Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility. It is used in the treatment of acute anaphylaxis. Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.

Other Notes

The ratio of +/- adrenaline is not determined.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311,H315,H319,H335
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges