E3526

Anti-phospho-Elk-1 (pSer³⁸³) antibody produced in rabbit

Name: Anti-phospho-Elk-1 (pSer<SUP>383</SUP>) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous glycerol solution

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Informacje o tej pozycji

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01092332

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Nazwa produktu

Anti-phospho-Elk-1 (pSer³⁸³) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

rat, mouse, human

technique(s)

western blot (chemiluminescent): 1:1,000 using Elk-1 fusion protein phosphorylated with purified Erk2

UniProt accession no.

P19419

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer383)

Quality Level

200

Gene Information

human ... ELK1(2002)
mouse ... Elk1(13712)
rat ... Elk1(314436)

Application

Anti-phospho-Elk-1 (pSer³⁸³⁾ antibody produced in rabbit is suitable for western blotting (chemiluminescent) at a dilution of 1:1,000 using Elk-1 fusion protein phosphorylated with purified Erk2.

Biochem/physiol Actions

ETS domain-containing protein Elk-1 is a protein encoded by the ELK1 gene in humans. It is a member of the Ets family of transcription factors. Elk-1 activation is important for executing its physiologic functions. Its activation is positively associated with ER and with Cyclin D1. Elk1 plays a novel role in controlling cell migration. Elk-1 is involved in a number of important cell processes through the activation of different genes in a number of normal tissues as well as in many malignancies. It is also plays a role in breast neoplasia.

The antibody detects Elk-1 protein only when phosphorylated at Ser³⁸³.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

synthetic phosphopeptide corresponding to residues around phosphorylated Ser³⁸³ of human Elk-1.

Physical form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol.

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Klasa składowania

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features.

Aggelos Laliotis et al.

Breast (Edinburgh, Scotland), 22(1), 89-95 (2012-11-07)

Recently an increased interest on Elk1 protein and its role in breast cancer evolution has been noted. This protein is an element of the Ets family of transcription factors and it has been involved in a number of important cell

LAP-like process as an immune mechanism downstream of IFN-γ in control of the human malaria Plasmodium vivax liver stage.

Rachasak Boonhok et al.

Proceedings of the National Academy of Sciences of the United States of America, 113(25), E3519-E3528 (2016-05-18)

IFN-γ is a major regulator of immune functions and has been shown to induce liver-stage Plasmodium elimination both in vitro and in vivo. The molecular mechanism responsible for the restriction of liver-stage Plasmodium downstream of IFN-γ remains uncertain, however. Autophagy

ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes.

Zaneta Odrowaz et al.

PLoS genetics, 8(5), e1002694-e1002694 (2012-05-17)

Eukaryotic transcription factors are grouped into families and, due to their similar DNA binding domains, often have the potential to bind to the same genomic regions. This can lead to redundancy at the level of DNA binding, and mechanisms are

Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma.

Jacqueline F Morris et al.

Human pathology, 44(5), 766-776 (2012-11-02)

Elk-1 is a member of the Ets family of transcription factors, which are identified by a conserved Ets DNA-binding domain that mediates transcriptional regulation at Ets sequence--containing promoters. The activation domain of Elk-1 is important for executing its physiologic functions

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Anti-phospho-Elk-1 (pSer383) antibody produced in rabbit