This product has not been validated for cell-based experiments. However, literature indicates that it has been used successfully in cell-based experiments. For more information, please see references provided on the product web page. https://www.sigmaaldrich.com/en/product/sigma/e3520
E3520
Ebselen
powder, ≥98% (TLC)
Synonim(y):
2-Phenyl-1,2-benzisoselenazol-3(2H)-one
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25 MG
1190,00 zł
100 MG
3640,00 zł
1190,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C13H9NOSe
Numer CAS:
Masa cząsteczkowa:
274.18
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Przejdź do
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Pozwól nam pomócNazwa produktu
Ebselen, cysteine modifier
SMILES string
O=C1N([Se]c2ccccc12)c3ccccc3
InChI
1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChI key
DYEFUKCXAQOFHX-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
mp
176-182 °C
solubility
chloroform: 19.60-20.40 mg/mL, clear, yellow
storage temp.
2-8°C
Quality Level
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1 of 4
Ta pozycja | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form powder | form powder | form powder | form powder |
| solubility chloroform: 19.60-20.40 mg/mL, clear, yellow | solubility DMSO: 5 mg/mL (clear solution) | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mp 176-182 °C | mp - | mp - | mp - |
General description
Ebselen is a sympathomimetic amine.
Application
Ebselen has been used as a:
extensor digitorum longus (fast-twitch) muscle
- voltage-dependent calcium channels (VDCCs) blocker[1]
- glutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouse
extensor digitorum longus (fast-twitch) muscle
- glucocerebrosidase inhibitor
- hepatitis C virus helicase inhibitor[2]
Biochem/physiol Actions
Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity. It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection. It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.
An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol.[3] Inhibits oxidation of low density lipoproteins (LDL).
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
Klasa składowania
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Diana Islam et al.
American journal of respiratory and critical care medicine, 199(10), 1214-1224 (2018-12-07)
Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS). Objectives: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS. Methods:
Chuanjiang Dong et al.
Frontiers in microbiology, 10, 3016-3016 (2020-02-06)
As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent antibacterial activity against Staphylococcus aureus. In this paper, we demonstrated that ebselen has
Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections
Thangamani S, et al.
Scientific reports, 5, 11596-11596 (2015)
Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening
Urban DJ, et al.
Combinatorial Chemistry & High Throughput Screening, 11(10), 817-824 (2008)
N Noguchi et al.
Biochimica et biophysica acta, 1213(2), 176-182 (1994-07-14)
The oxidative modification of low density lipoprotein (LDL) is accepted to be an important early event of atherosclerosis, but it has not yet been well understood. The preventive effects of two antioxidants with different functions, ebselen and probucol, against the
Produkty
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
Uncover properties and applications of the cysteine protease papain and find inhibitors, substrates, and other papain products.
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Hello, we recently ordered this product (Ebselen, Cat# E3520). I dissolved it in DMSO (5 mg/mL) and plan to use it in cell experiments. However, I just noticed that the purity is ≥98% (TLC). Would this be suitable for cell-based experiments.Thank you.
1 answer-
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