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Merck

E1532

Monoclonal Anti-E2F6 antibody produced in mouse

~1.0 mg/mL, clone TFE61, purified immunoglobulin, buffered aqueous solution

Synonim(y):

Anti-E2F transcription factor 6, Anti-E2F-6

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Informacje o tej pozycji

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
TFE61, monoclonal
Application:
immunocytochemistry
indirect ELISA
western blot
Species reactivity:
human
Citations:
7
Technique(s):
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 2-4 μg/mL using HeLa nuclear cell extract
Uniprot accession no.:
O75461

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Nazwa produktu

Monoclonal Anti-E2F6 antibody produced in mouse, ~1.0 mg/mL, clone TFE61, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

TFE61, monoclonal

form

buffered aqueous solution

mol wt

antigen ~35 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 2-4 μg/mL using HeLa nuclear cell extract

isotype

IgG1

UniProt accession no.

O75461

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... E2F6(1876)

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Application

Monoclonal Anti-E2F6 antibody produced in mouse is suitable for immunocytochemistry and indirect ELISA. It is also suitable for western blotting at a working concentration of 2-4μg/mL using HeLa nuclear cell extract.

Biochem/physiol Actions

The third class of E2Fs lacks both the retinoblastoma protein binding and transcriptional activation domain, and is an active repressor of transcription. The activity of E2F6 is mediated through its recruitment of polycomb transcriptional repressor complexes in a histone methylation independent manner. E2F6 associates with E2F target genes that are activated at G1/S phase. Its repression activity during the S-phase distinguishes G1/S and G2/M transcription during cell cycle. It may be involved in various cancerous processes.

General description

E2F6 transcription factor belongs to the third class of E2Fs. The E2F transcription factors are a family of genes that play critical roles in regulation of cellular proliferation and differentiation.

Immunogen

recombinant human E2F6 protein

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Klasa składowania

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number
068K4789

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Phillip J Iaquinta et al.
Current opinion in cell biology, 19(6), 649-657 (2007-11-23)
The E2F transcription factors are critical regulators of genes required for appropriate progression through the cell cycle, and in special circumstances they can also promote the expression of another class of genes that function in the apoptotic program. Since E2Fs
Gwen MacDonald et al.
Breast cancer research : BCR, 9(4), R49-R49 (2007-08-01)
Decreased transcription of the BRCA1 gene has previously been observed to occur in sporadic breast tumours, making elucidation of the mechanisms regulating the expression of this gene important for our understanding of the etiology of the disease. Transcriptional elements involved
J M Trimarchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(6), 2850-2855 (1998-04-18)
The E2F family of proteins is required to establish the correct cell-cycle-dependent transcription of genes that direct the process of cell division. All previously identified E2F proteins can act in a similar manner; depending on whether or not they are
Paloma H Giangrande et al.
Genes & development, 18(23), 2941-2951 (2004-12-03)
E2F transcription factors play a critical role in the control of cell cycle progression, regulating the expression of genes involved in DNA replication, DNA repair, mitosis, and cell fate. This involves both positive-acting and negative-acting E2F proteins, the latter group
J M Trimarchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(4), 1519-1524 (2001-02-15)
The E2F transcription factors play a key role in the regulation of cellular proliferation and terminal differentiation. E2F6 is the most recently identified and the least well understood member of the E2F family. It is only distantly related to the
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Data Sheet - E1532

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