D101

(±)-DOI hydrochloride

≥98% (HPLC), solid,  5-HT2 serotonin receptor agonist

• Synonim(y): (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride, (±)-DOI
• Wzór empiryczny (zapis Hilla): C₁₁H₁₆INO₂ · HCl
• Numer CAS: 42203-78-1
• Masa cząsteczkowa: 357.62
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278092
• NACRES: NA.77
• MDL number: MFCD00055199

Właściwości

• Nazwa produktu: (±)-DOI hydrochloride, ≥98% (HPLC), solid
• SMILES string: NC(C)CC1=CC(OC)=C(I)C=C1OC.Cl
• InChI: 1S/C11H16INO2.ClH/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2;/h5-7H,4,13H2,1-3H3;1H
• InChI key: QVFDMWGKHUFODK-UHFFFAOYSA-N
• assay: ≥98% (HPLC)
• form: solid
• drug control: Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada; kontrollierte Droge in Deutschland
• Quality Level: 100
• Gene Information: human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)
• color: white to off-white
• solubility: H₂O: 10 mg/mL; ethanol: 2 mg/mL

Opis

Biochem/physiol Actions

(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves