C6046

20-Carboxy-leukotriene B4

Name: 20-Carboxy-leukotriene B4
Brand: SIGMA

~1 mg/mL in ethanol, ≥90% (HPLC)

Synonim(y):

20-Carboxy-LTB4

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₀H₃₀O₆

Numer CAS:

80434-82-8

Masa cząsteczkowa:

366.45

UNSPSC Code:

12352211

PubChem Substance ID:

24892831

MDL number:

MFCD00065857

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InChI

1S/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-18,21-22H,1,3,9-11,14-16H2,(H,23,24)(H,25,26)/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m1/s1

SMILES string

O[C@@H](CCCC(O)=O)/C=C\C=C\C=C\[C@H](O)C\C=C/CCCCC(O)=O

InChI key

SXWGPVJGNOLNHT-VFLUTPEKSA-N

assay

≥90% (HPLC)

form

liquid

concentration

~1 mg/mL in ethanol

functional group

carboxylic acid

shipped in

dry ice

storage temp.

−20°C

pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H315,H319,H335

pcodes

P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

3 - Flammable liquids

wgk

WGK 3

flash_point_f

57.2 °F

flash_point_c

14 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certyfikaty analizy (CoA)

Lot/Batch Number

026H0957

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

High-performance liquid chromatography-thermospray mass spectrometry of omega-carboxyleukotriene B4 and omega-hydroxyleukotriene B4 from an incubation mixture of human colonic well-differentiated adenocarcinoma homogenate.

M Yamane et al.

Journal of chromatography. B, Biomedical applications, 666(2), 197-202 (1995-04-21)

A method for the analysis of omega-carboxyleukotriene B4 and omega-hydroxyleukotriene B4 in human colonic carcinoma homogenate is described. The hydroxy groups of the leukotriene metabolite were acetylated by acetic anhydride, and the mixture was partially purified on a Sep-Pak C18

Hepatic microsomal metabolism of leukotriene B4 in rats: biochemical characterization, effect of inducers, and age- and sex-dependent differences.

H Mukhtar et al.

Xenobiotica; the fate of foreign compounds in biological systems, 19(2), 151-159 (1989-02-01)

1. The cytochrome P-450-dependent metabolism of leukotriene B4 (LTB4) by rat hepatic microsomes was characterized. Hepatic microsomes were found to metabolize LTB4 to 20-hydroxy-LTB4 and 20-carboxy:LTB4. The rate of formation of 20-hydroxy-LTB4 (14.6 pmol/min per mg protein) was 5.8-fold higher

Association of leukotriene B4 with the cytoskeleton of rabbit neutrophils. Effect of chemotactic factor and phorbol esters.

P H Naccache et al.

Biochemical and biophysical research communications, 124(3), 963-969 (1984-11-14)

Following its addition to a suspension of rabbit neutrophils, leukotriene B4 is rapidly (less than 1 min) recovered from the cytoskeletal fraction (Triton X-100 insoluble pellet) of these cells. The association of leukotriene B4 with the cytoskeleton can be competed

Stereochemical analysis and biological activity of 3-hydroxy-leukotriene B4: a metabolite from ethanol-treated rat hepatocytes.

P Wheelan et al.

The Journal of pharmacology and experimental therapeutics, 271(3), 1514-1519 (1994-12-01)

Leukotriene B4 (LTB4), a biologically active metabolite derived from arachidonic acid by the 5-lipoxygenase cascade, is inactivated by cytochrome P-450-dependent omega-hydroxylation followed by second oxidation into a omega-carboxyl group. In many tissues, this second step is mediated by alcohol dehydrogenase.

NAD+-dependent oxidation of 20-hydroxyleukotriene B4 to 20-carboxyleukotriene B4 by rat liver cytosol.

Y Gotoh et al.

Biochimica et biophysica acta, 960(3), 342-350 (1988-06-15)

20-Hydroxyleukotriene B4 was converted by rat liver homogenates in the presence of NAD+ to a more polar product on reverse-phase high-performance liquid chromatography. The product was identified as 20-carboxyleukotriene B4 by straight-phase high performance liquid chromatography, ultraviolet spectrophotometry and gas

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