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C5612
Anti-CD30 Ligand antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonim(y):
Anti-CD30L
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About This Item
Numer MDL:
Kod UNSPSC:
12352203
pochodzenie biologiczne
goat
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Formularz
lyophilized powder
reaktywność gatunkowa
mouse
metody
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
mouse ... Tnfsf8(21949)
Opis ogólny
CD30 Ligand (CD30L) is a type II membrane glycoprotein of the tumor necrosis factor (TNF) superfamily. It is expressed on the cell surface of activated T cells, B cells, and monocytes. CD30L is also present in other cells, including mature dendritic cells, macrophages and mast cells. CD30L is also reffered to as Tnfsf8 (Tumor necrosis factor ligand superfamily member 8).
Immunogen
purified recombinant mouse CD30 ligand (amino acids 68-239) extracellular domain, expressed in NSO cells.
Zastosowanie
Anti-CD30 antibody produced in goat is suitable for indirect ELISA at a concentration of 0.5-1.0μg/mL and western blotting at a concentration of 0.1-0.2μg/mL.
Działania biochem./fizjol.
CD30L (CD30 ligand) along with CD30 is involved in activation and proliferation of T and B cells. They are also involved in the regulation of initial artherosclerosis development. CD30L/CD30 is crucial for maintenance and activation of IL (Interleukin)-17A-producing γδ T cells. CD30L/CD30 causes down-regulation of IL-2, resulting in Th17 differentiation of CD4+ T cells. CD30L helps in memory phenotype CD4+ T cells-mediated protection against infection with Listeria monocytogenes. CD30L/CD30 signaling is critical for Th1 response against Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection. They are also linked to allergic rhinitis pathogenesis in mice. CD30L/CD30 signaling is involved in pathogenesis of inflammatory bowel diseases.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
13 - Non Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
H J Gruss et al.
The American journal of pathology, 149(2), 469-481 (1996-08-01)
The CD30 ligand (CD30L) is a type II transmembrane glycoprotein of the tumor necrosis factor ligand superfamily. Recent cloning of CD30L has enabled studies to explore its function and tissue distribution. For instance, recombinant CD30L has been shown to co-stimulate
X Sun et al.
Mucosal immunology, 6(6), 1191-1201 (2013-04-04)
CD30 ligand (CD30L, CD153), a member of the tumor necrosis factor (TNF) superfamily, and its receptor CD30 are important for differentiation and activation of CD4(+) T helper type 17 (Th17) cells. In this report, we demonstrate that the interleukin 17A
Xun Sun et al.
Journal of immunology (Baltimore, Md. : 1950), 185(4), 2222-2230 (2010-07-20)
A CD30 ligand (CD30L; CD153) and its receptor, CD30, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily. These were expressed preferentially by activated CD4(+)T cells. In this paper, we show that CD44(low)CD62(hi)CD4(+) T cells from CD30L(-/-)
Kenji Umeda et al.
Microbiology and immunology, 55(9), 645-656 (2011-06-28)
CD30 ligand (CD30L, CD153) is a type II membrane-associated glycoprotein belonging to the tumor necrosis factor family. It is shown here that CD30L knock out (KO) mice are highly susceptible to primary infection with Listeria monocytogenes as assessed by the
Amanda C Foks et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(12), 2862-2868 (2012-10-23)
Costimulatory molecules tightly control immune responses by providing positive signals that promote T-cell activation or by transducing inhibitory signals that limit T-cell responses. CD30 and CD30L are members of the tumor necrosis factor receptor superfamily and are involved in the
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