C3021

Dicyanocobinamide

≥93%

• Synonim(y): Cobinamide dicyanide, Etiocobalamin, Factor B
• Wzór empiryczny (zapis Hilla): C₅₀H₇₂CoN₁₃O₈
• Numer CAS: 27792-36-5
• Masa cząsteczkowa: 1042.12
• NACRES: NA.79
• PubChem Substance ID: 24892558
• UNSPSC Code: 12352205
• MDL number: MFCD00056330

Właściwości

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥93%
• form: powder
• impurities: ≤0.1% vitamin B₁₂
• color: purple to very dark purple
• storage temp.: −20°C
• SMILES string: N#C[Co]C#N.C[C@H](O)CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)C2N=C1C(C)=C3N=C(C=C4N=C(C(C)=C5N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O
• InChI: 1S/C48H73N11O8.2CN.Co/c1-23(60)22-55-38(67)16-17-45(6)29(18-35(52)64)43-48(9)47(8,21-37(54)66)28(12-15-34(51)63)40(59-48)25(3)42-46(7,20-36(53)65)26(10-13-32(49)61)30(56-42)19-31-44(4,5)27(11-14-33(50)62)39(57-31)24(2)41(45)58-43;2*1-2;/h19,23,26-29,43,59-60H,10-18,20-22H2,1-9H3,(H2,49,61)(H2,50,62)(H2,51,63)(H2,52,64)(H2,53,65)(H2,54,66)(H,55,67);;;/b30-19-,39-24-,40-25-;;;/t23-,26+,27+,28+,29-,43?,45+,46-,47-,48-;;;/m0.../s1
• InChI key: NJATWHPHZUGTHR-GXEWULDJSA-N

Opis

General description

Dicyanocobinamide, also known as factor b is a coenzyme B12 precursor. It has a corrin ring structure with four of the six coordination sites of the cobalt (Co) atom being the pyrrole nitrogen atoms.

Application

For use in determining non-intrinsic factor (R protein) in intrinsic factor preparations.

Dicyanocobinamide has been used for the crystallization of vitamin B₁₂-binding protein (BtuF). It has also been used for the destabilization of BtuCD-BtuF Interaction.

Biochem/physiol Actions

Dicyanocobinamide (Cbi) functions as a soluble guanylate cyclase (sGC) co-activator and targets the N-terminal regulatory regions. This action is similar to the effect of forskolin on adenylyl cyclases. Dicyanocobinamide elevates the intracellular cyclic guanosine monophosphate (cGMP) levels and exhibits vasorelaxant activity in rats. It is used along with various cobalamins in studies of the inhibition of HIV-1 integrase and nitric oxide synthase.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable