C2149

Cytochalasin E from Aspergillus clavatus

Name: Cytochalasin E from <I>Aspergillus clavatus</I>
Brand: SIGMA

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₈H₃₃NO₇

Numer CAS:

36011-19-5

Masa cząsteczkowa:

495.56

UNSPSC Code:

12352200

NACRES:

NA.77

PubChem Substance ID:

24892467

EC Number:

252-835-7

Beilstein/REAXYS Number:

1096975

MDL number:

MFCD00005178

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InChI key

LAJXCUNOQSHRJO-ZYGJITOWSA-N

InChI

1S/C28H33NO7/c1-16-9-8-12-19-23-27(4,35-23)17(2)21-20(15-18-10-6-5-7-11-18)29-24(31)28(19,21)36-25(32)34-14-13-26(3,33)22(16)30/h5-8,10-14,16-17,19-21,23,33H,9,15H2,1-4H3,(H,29,31)/b12-8+,14-13+/t16-,17-,19-,20-,21-,23-,26+,27+,28+/m0/s1

SMILES string

C[C@H]1C\C=C\[C@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]4[C@H](Cc5ccccc5)NC(=O)[C@@]24OC(=O)O\C=C\[C@@](C)(O)C1=O

form

powder

storage temp.

−20°C

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Application

Cytochalasin E has been used as:

a toxin to study its effects on avocado plants[1]
a component of the incubating medium in feline junctional adhesion molecule 1 (fJAM-1) expression assay[2]
an inhibitor of actin polymerization to study its effects on mitochondria uptake by mice endothelial cells[3]

Biochem/physiol Actions

Cytochalasin E is a cell-permeable fungal toxin that inhibits actin polymerization stimulated by F-actin. Cytochalasin E does not inhibit glucose transport.

Cytochalasin E is an epoxide[4] that exhibits anti-proliferative activity in endothelial cells in vitro. It also participates in inhibiting tumor growth and angiogenesis in vivo.[5] Cytochalasin E also possesses antimicrobial and antiviral properties.[4]

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300 + H310 + H330,H361

pcodes

P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2

Klasa składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Cytochalasin E in the lichen Pleurosticta acetabulum. Anti-proliferative activity against human HT-29 colorectal cancer cells and quantitative variability.

Sylvie Delebassée et al.

Fitoterapia, 121, 146-151 (2017-07-15)

A biological screening of sixteen lichen extracts on human HT-29 colorectal cancer cells, led to the selection of Pleurosticta acetabulum, a lichen widely present in tree barks in Europe. Bioguided purification of the acetonic extract resulted in the isolation of

Circulating mitochondria in organ donors promote allograft rejection.

Liwen Lin et al.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19(7), 1917-1929 (2019-02-15)

The innate immune system is a critical regulator of the adaptive immune responses that lead to allograft rejection. It is increasingly recognized that endogenous molecules released from tissue injury and cell death are potent activators of innate immunity. Mitochondria, ancestrally

Anticancer fungal natural products: Mechanisms of action and biosynthesis.

Siwen Yuan et al.

European journal of medicinal chemistry, 202, 112502-112502 (2020-07-12)

Many fungal metabolites show promising anticancer properties both in vitro and in animal models, and some synthetic analogs of those metabolites have progressed into clinical trials. However, currently, there are still no fungi-derived agents approved as anticancer drugs. Two potential reasons

Characterization of the high cytochalasin E and rosellichalasin producing-Aspergillus sp. nov. F1 isolated from marine solar saltern in China.

Lin Xiao et al.

World journal of microbiology & biotechnology, 29(1), 11-17 (2012-08-23)

A moderately halophilic fungus F1 was isolated from a marine solar saltern in Weihai, China. The identification of the fungus F1 was performed by the morphological characteristics, physiological and biochemical tests as well as phylogenetic analysis based on ITS (internal

Non-opsonic phagocytosis of homologous non-toxigenic and toxigenic Corynebacterium diphtheriae strains by human U-937 macrophages.

Cíntia Silva dos Santos et al.

Microbiology and immunology, 54(1), 1-10 (2010-01-09)

As interactions between bacteria and macrophages dictate the outcome of most infectious diseases, analyses of molecular mechanisms of non-opsonic phagocytosis should lead to new approaches for the prevention of diphtheria and systemic Corynebacterium diphtheriae infections. The present study aimed to

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