C156

D-CPT tartrate

Name: <SC>D</SC>-CPT tartrate
Brand: SIGMA

>94%, solid

Synonim(y):

β-CPT tartrate, (–)-2β-Carbomethoxy-3β-phenyltropane tartrate, Troparil tartrate, WIN 35,065-2

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₆H₂₁NO₂ · C₄H₆O₆

Numer CAS:

50372-80-0

Masa cząsteczkowa:

409.43

UNSPSC Code:

12352202

PubChem Substance ID:

329774896

NACRES:

NA.77

Assay:

>94%

Form:

solid

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assay

>94%

form

solid

optical activity

[α]22/D −95.9°, c = 1.1 in H₂O(lit.)

drug control

USDEA Schedule II; Home Office Schedule 2; regulated under CDSA - not available from Sigma-Aldrich Canada

color

white

solubility

H₂O: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

OC(C(O)C(O)=O)C(O)=O.COC(=O)[C@@H]1C2CCC(C[C@@H]1c3ccccc3)N2C

InChI

1S/C16H21NO2.C4H6O6/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11;5-1(3(7)8)2(6)4(9)10/h3-7,12-15H,8-10H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t12-,13+,14+,15-;/m0./s1

InChI key

WYGLYLVLBCZESH-PEVLCXCCSA-N

Biochem/physiol Actions

Binds to the cocaine receptor site on the dopamine transporter and blocks dopamine uptake.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Hygroscopic

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality.

Emily M Jutkiewicz et al.

Annals of emergency medicine, 54(3), 409-420 (2008-11-18)

Cocaine toxicity results in cardiovascular complications, seizures, and death and accounts for approximately 20% of drug-related emergency department visits every year. Presently, there are no treatments to eliminate the toxic effects of cocaine. The present study hypothesizes that a bacterial

Effect of repeated administration of various doses of cocaine and WIN 35,065-2 on locomotor behavior of mice.

M E Reith

European journal of pharmacology, 130(1-2), 65-72 (1986-10-14)

Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg per day for cocaine

Saturable (3H)cocaine binding in central nervous system of mouse.

M E Reith et al.

Life sciences, 27(12), 1055-1062 (1980-09-22)

Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites.

A Brouard et al.

Brain research. Developmental brain research, 75(1), 13-17 (1993-09-17)

The cellular localization of the cocaine binding sites in primary cultures of embryonic rat mesencephalic cells was previously reported to differ from that observed in adult rat brain. In order to know whether this different localization was associated with a

Repeated injection of GBR 12909, but not cocaine or WIN 35,065-2, into the ventral tegmental area induces behavioral sensitization.

J D Steketee

Behavioural brain research, 97(1-2), 39-48 (1998-12-29)

A role for the mesolimbic dopamine system in the development of behavioral sensitization to psychostimulants, such as cocaine and amphetamine, is well established. Previous reports have suggested that the ventral tegmental area (VTA) is involved in the initiation of, while

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
C156-5MG	04061832269825

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