C1254

Sodium cholate hydrate

from bovine and/or ovine bile, ≥99%

• Synonim(y): 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholalic acid sodium salt
• Wzór empiryczny (zapis Hilla): C₂₄H₃₉NaO₅ · xH₂O
• Numer CAS: 206986-87-0
• Masa cząsteczkowa: 430.55 (anhydrous basis)
• UNSPSC Code: 12161900
• NACRES: NA.25
• PubChem Substance ID: 24892390
• EC Number: 206-643-5
• Beilstein/REAXYS Number: 3582354
• MDL number: MFCD00150749

Właściwości

• Quality Segment: 200
• biological source: bovine and/or ovine bile
• description: anionic
• assay: ≥99%
• form: powder
• mol wt: micellar avg mol wt 900-1300
• aggregation number: 2-3
• technique(s): DNA purification: suitable, RNA purification: suitable, western blot: suitable
• CMC: 9-15 mM (20-25°C)
• solubility: water: 100 mg/mL, clear, colorless to light yellow
• HLB: 18
• SMILES string: O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C
• InChI: 1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1
• InChI key: MUVVIYFKOVLQHL-RCVKHMDESA-M

Opis

General description

Sodium cholate hydrate, a non-denaturing anionic detergent, plays a crucial role in biochemical research, particularly in protein solubilization and membrane permeabilization, making it essential for protein extraction and purification, especially when dealing with membrane proteins and protein complexes. Derived from cholic acid, a prevalent human bile acid, sodium cholate hydrate′s water solubility and its applications extend to investigating the effects of various substances on cell cultures, making it a versatile tool in laboratory research.

Application

Sodium cholate hydrate has been used in a study to assess the effect of phospholipid formulation and surfactants on the dermal delivery of hydrophilic drugs from elastic liposomes. [1] It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.

Biochem/physiol Actions

Bile Salt

Features and Benefits

• Suitable for Western blotting
• Suitable for DNA and RNA purification
• High purity product for research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

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Informacja o środkach bezpieczeństwa

• hcodes: H412
• pcodes: P273 - P501
• Hazard Classifications: Aquatic Chronic 3
• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)