C125

(±)-CGP-12177A

Name: (±)-CGP-12177A
Brand: SIGMA
Price: 1100 PLN

≥98% (HPLC), solid

Synonim(y):

(±)-CGP-12177 hydrochloride, 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1, 3-dihydro-2H-benzimidazol-2-one hydrochloride

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50 MG

1100,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₄H₂₁N₃O₃ · HCl

Numer CAS:

64208-32-8

Masa cząsteczkowa:

315.80

NACRES:

NA.77

PubChem Substance ID:

24277768

UNSPSC Code:

12352200

MDL number:

MFCD00069230

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Nazwa produktu

(±)-CGP-12177A, ≥98% (HPLC), solid

InChI

1S/C14H21N3O3.ClH/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10;/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19);1H

SMILES string

Cl.CC(C)(C)NCC(O)COc1cccc2NC(=O)Nc12

InChI key

YQVFCYCTITZLSX-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >10 mg/mL

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Ta pozycja	D9190	SML0362	B4313
Sigma-Aldrich C125 (±)-CGP-12177A	Sigma-Aldrich D9190 DCEBIO	Sigma-Aldrich SML0362 NPS2143 hydrochloride	Sigma-Aldrich B4313 (E/Z)-BCI hydrochloride
form solid	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: >10 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: 10 mg/mL, clear
color white	color white to off-white	color white to beige	color white to beige
Gene Information human ... ADRB1(153), ADRB2(154), ADRB3(155)	Gene Information human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)	Gene Information -	Gene Information -

Application

(±)-CGP-12177A has been used as a β-Adrenergic receptor agonist:

to evaluate the dissociation constant (Kd) by frontal affinity chromatography[1]
to study its cardiostimulant effects on rat ventricular cardiomyocytes[2]
to study its binding affinity in α_1D-adrenoceptors expressed in rat BHK-21 cells[3]

Biochem/physiol Actions

β-adrenoceptor nonconventional partial agonist.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology.

Clive J Lewis et al.

British journal of pharmacology, 141(5), 813-824 (2004-02-06)

1. CGP 12177A mediates cardiostimulation by activation of the 'putative' beta(4)-adrenoceptor; however, it has recently been reported that disruption of the beta(1)-adrenoceptor gene abolishes this effect. We have adenovirally overexpressed beta(1)-adrenoceptors in isolated, cultured adult rat ventricular cardiomyocytes and observed

Comparison of the binding affinity of CGP-12177A at recombinant rat alpha(1D)-adrenoceptors expressed in BHK-21 cell membranes and alpha(1)-adrenoceptors present in rat cerebral cortex membranes.

Maura Floreani et al.

European journal of pharmacology, 590(1-3), 303-309 (2008-07-01)

Recent in vitro studies, performed in rat aorta, mesenteric and intrapulmonary arteries, and human pulmonary artery, demonstrated that the beta-adrenoceptor ligand CGP-12177A (4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one) is also provided with antagonist or partial agonist properties at alpha(1)-adrenoceptors. These observations were supported by estimates

In vivo effects of CGP-12177 on the expression of leptin and uncoupling protein genes in mouse brown and white adipose tissues.

P Oliver et al.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 24(4), 423-428 (2000-05-11)

To assess the effect of chronic treatment with CGP-12177 a beta3-adrenergic receptor (AR) agonist with beta2/beta1-AR antagonist action, on the expression of the leptin gene and of genes coding for uncoupling proteins (ucp1, ucp2 and ucp3) in brown and white

The effects of beta-adrenoceptor agonists on KCl-induced rhythmic contraction in the ureter of guinea pig.

Y Yamamoto et al.

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 36(1), 13-19 (2000-06-01)

In the present study, we tried to determine what effects were induced by beta-adrenoceptor agonists on 40 mM KCl-induced rhythmic contraction and to clarify which beta-adrenoceptor subtypes are involved in the regulation of ureter motility in the guinea pig by

Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wildtype and beta(3)-adrenoceptor knockout mice.

J Oostendorp et al.

British journal of pharmacology, 130(4), 747-758 (2000-06-24)

The smooth muscle relaxant responses to the mixed beta(3)-, putative beta(4)-adrenoceptor agonist, (-)-CGP 12177 in rat colon are partially resistant to blockade by the beta(3)-adrenoceptor antagonist SR59230A suggesting involvement of beta(3)- and putative beta(4)-adrenoceptors. We now investigated the function of

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(±)-CGP-12177A