C1119

Caroverine hydrochloride

Name: Caroverine hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonim(y):

1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₂H₂₈ClN₃O₂

Numer CAS:

55750-05-5

Masa cząsteczkowa:

401.93

UNSPSC Code:

12352200

PubChem Substance ID:

329774856

MDL number:

MFCD01684929

Assay:

≥98% (HPLC)

Form:

solid

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assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Cl.CCN(CC)CCN1C(=O)C(Cc2ccc(OC)cc2)=Nc3ccccc13

InChI

1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H

InChI key

JRNWTJUIMRLKBV-UHFFFAOYSA-N

Biochem/physiol Actions

Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist.

Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist. Also, Caroverine hydrochloride is a class B calcium-channel-blocker, antiglutamatergic agent, and acts as an antioxidant when administered to lab animals.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Klasa składowania

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certyfikaty analizy (CoA)

Lot/Batch Number

058K4601

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Tinnitus: pharmacological topodiagnosis.

Dario Alpini et al.

The international tinnitus journal, 10(1), 91-93 (2004-09-24)

The difficulty of accurately localizing the source of subjective tinnitus is well-known. Anamnesis and traditional audiological tests can often suggest a source if its origin as peripheral or merely central (or both). Therefore, several authors, such as Risey, Denk, and

Analysis of 60 patients after tympanotomy and sealing of the round window membrane after acute unilateral sensorineural hearing loss.

Claudia Gedlicka et al.

American journal of otolaryngology, 30(3), 157-161 (2009-05-05)

This retrospective study was performed to evaluate the effectiveness of tympanotomy and sealing of the round window membrane after unilateral acute hearing loss. All patients presenting idiopathic sudden hearing loss, acoustic, or barotrauma were treated with prednisolone and caroverine. Thirty-six

[Changes of synaptoarchitecture of the retina after the light-induced damage and their correction by plant antioxidants].

S V Logvinov et al.

Morfologiia (Saint Petersburg, Russia), 133(1), 46-50 (2008-12-17)

The changes of interneuronal contacts in the internal reticular layer of albino rat retina were studied 7 and 30 days after the exposure to high intensity light (6000 Lux for 6 h). In osmicated preparations, the "light" type of synapse

Acute treatment of noise trauma with local caroverine application in the guinea pig.

Zhiqiang Chen et al.

Acta oto-laryngologica, 123(8), 905-909 (2003-11-11)

Intense sound stimulation may result in excessive glutamate release from the inner hair cells, resulting in binding to the postsynaptic glutamate receptors and leading to neuronal degeneration and functional impairment. In this study we investigated the therapeutic effect and time

The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof-of-concept study.

Christian Quint et al.

Acta oto-laryngologica, 122(8), 877-881 (2003-01-25)

The treatment of non-conductive olfactory disorders is to a large extent an unsolved problem. This proof-of-concept study focused on possible effects of the N-methyl-D-aspartate (NMDA) antagonist caroverine. Potential mechanisms for the hypothesized effect included reduced feedback inhibition in the olfactory

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
C1119-10MG	04061832081328
C1119-50MG	04061832081335

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