B3680
Monoclonal Anti-Bone Morphogenetic Protein 6 antibody produced in mouse
clone 74219.11, purified immunoglobulin, lyophilized powder
Synonim(y):
Anti-BMP-6
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About This Item
pochodzenie biologiczne
mouse
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
74219.11, monoclonal
Postać
lyophilized powder
reaktywność gatunkowa
human
metody
capture ELISA: suitable
neutralization: suitable
western blot: 1-2 μg/mL
izotyp
IgG2b
numer dostępu UniProt
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... BMP6(654)
Opis ogólny
Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. BMP-6 regulates both T cell and B cell-mediated immunity. It acts through Smad and p38 pathway to induce the expression of IL-6. Additionally, it induces the expression of iNOS by macrophages through the activation of NF-κB and STAT pathways. BMP-6 is a stimulator of differentiation of liver, bone, neuronal tissue and embryonic kidney and urinary systems. Studies also indicate that BMP-6 is important in the regulation of liver hormone, hepcidin, expression that is important to maintain systemic iron balance
Monoclonal Anti-Bone Morphogenetic Protein 6 recognizes human BMP-6. The antibody shows no cross-reactivity with recombinant human (rh) BMP-2, rhBMP-4, rhBMP-5, and rhBMP-7.
Monoclonal Anti-Bone Morphogenetic Protein 6 recognizes human BMP-6. The antibody shows no cross-reactivity with recombinant human (rh) BMP-2, rhBMP-4, rhBMP-5, and rhBMP-7.
Immunogen
recombinant human BMP-6.
Zastosowanie
Anti-Bone Morphogenetic Protein 6 antibody may be used for immunoblotting at a working concentration of 1.0-2.0 μg/ml. For capture ELISA a concentration of 4 μg/ml is recommemnded. The antibody is also suitable for neutralization reactions.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Uwaga dotycząca przygotowania
Purified using protein G.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
13 - Non Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Jun Hyuk Hong et al.
Immunology, 128(1 Suppl), e442-e450 (2009-02-05)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor (TGF)-beta superfamily which regulates bone formation, haematopoiesis and development. While TGF-beta is known to be a negative regulator of the immune system, the effect of BMPs on the immune
Seok J Kwon et al.
Immunology, 128(1 Suppl), e758-e765 (2009-09-25)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGF-beta) superfamily. In the present study, we investigated the effect of BMPs on the production of inducible nitric oxide synthase (iNOS) in the murine macrophage cell line, RAW 264.7
Elena Corradini et al.
Hepatology (Baltimore, Md.), 54(1), 273-284 (2011-04-14)
The bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway is a central regulator of hepcidin expression and systemic iron balance. However, the molecular mechanisms by which iron is sensed to regulate BMP6-SMAD signaling and hepcidin expression are unknown. Here we examined
Geun Taek Lee et al.
The Journal of biological chemistry, 285(50), 39401-39408 (2010-10-05)
Unlike the prototype transforming growth factor-β (TGF-β), bone morphogenetic protein-6 (BMP-6) activates macrophages. Here, we report that BMP-6 induces the expression of IL-6 in macrophages. Using overexpression and knockdown experiments, we demonstrate that BMP receptor type II and activin-like kinase-2
Kohei Miyazono et al.
Cytokine & growth factor reviews, 16(3), 251-263 (2005-05-06)
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various
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