B3183

Anti-BID antibody produced in rabbit

Name: Anti-BID antibody produced in rabbit
Brand: SIGMA

Cleavage site [59/60] specific, affinity isolated antibody, buffered aqueous glycerol solution

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Informacje o tej pozycji

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02095892

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Nazwa produktu

Anti-BID antibody produced in rabbit, Cleavage site [59/60] specific, affinity isolated antibody, buffered aqueous glycerol solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen 15 kDa

species reactivity

mouse

technique(s)

microarray: suitable
western blot: suitable using mouse L929 cells treated with TNF-α

UniProt accession no.

P70444

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

mouse ... Bid(12122)

Application

Polyclonal anti-BID antibody produced in rabbit is suitable for western blotting by using mouse L929 cells treated with TNF-α. It is also suitable for microarray.

Biochem/physiol Actions

The protein encoded by this gene is a member of the BCL-2 family of cell death regulators and is localized on to chromosome 22q11.2. BID is activated by caspase 8 in response to Fas/TNF-R1 receptor activation. Activated BID then translocated to mitochondria where it induces cytochrome c release, which in turn activates downstream caspases. It is a BH3 interacting death domain that heterodimerizes with either agonist BAX or antagonist BCL2. BID initiates apoptosis by binding to regulatory sites on prosurvival BCL2 proteins to directly neutralize their function. Additionally, BID interacts with cathepsins play an important role in the actions of Camptothecin on breast cancer cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

synthetic peptide corresponding to N-terminal of cleavage site [59/60] of mouse BID.

Physical form

Supplied as a solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.

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10 - Combustible liquids

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Odwiedź Bibliotekę dokumentów

The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6.

T K Footz et al.

Genomics, 51(3), 472-475 (1998-08-29)

Cat eye syndrome (CES) is associated with a duplication of a segment of human chromosome 22q11.2. Only one gene, ATP6E, has been previously mapped to this duplicated region. We now report the mapping of the human homologue of the apoptotic

Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin.

M Lamparska-Przybysz et al.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 56 Suppl 3, 159-179 (2005-08-04)

The details of molecular switching points between apoptosis and autophagy in tumor cells have still not been fully elucidated. This study focused on the role of cathepsin B and its substrate, BID as molecular links between apoptosis and autophagy in

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

H Li et al.

Cell, 94(4), 491-501 (1998-09-04)

We report here that BID, a BH3 domain-containing proapoptotic Bcl2 family member, is a specific proximal substrate of Casp8 in the Fas apoptotic signaling pathway. While full-length BID is localized in cytosol, truncated BID (tBID) translocates to mitochondria and thus

Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697.

Vijay Agarwal et al.

International journal of oncology, 42(3), 1088-1092 (2013-01-23)

We have previously shown that specific COX-2 inhibitors, including DuP 697, have anti-proliferative effects on mesothelioma cells and potentiate the cytotoxicity of pemetrexed. Here, we used a novel proteomic approach to explore the mechanism of action of this agent. COX-2-positive

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