This product is constructed with a single deletion of Asp from the N-terminus to create a hypoallergenic construct. Structural equivalence to native albumin is confirmed by x-ray crystallography. The Asp deletion eliminates an important antigenic determinant by removing the principal copper and nickel binding site of albumin. The first three residues of human albumin are considered non-structural. Additionally, the product is blocked at Cys34 to improve stability, monomer content, and homogeneity.
A7736
Albumin human
recombinant, expressed in Pichia pastoris, lyophilized powder, ≥90% (agarose gel electrophoresis)
Synonim(y):
Albagen™, rHSA
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1 G
819,00 zł
819,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C2936H4624N786O889S41
Numer CAS:
Masa cząsteczkowa:
66471.53
UNSPSC Code:
12352202
NACRES:
NA.25
EC Number:
274-272-6
MDL number:
eCl@ss:
42010201
Biological source:
human
Assay:
≥90% (agarose gel electrophoresis)
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
Przejdź do
Pomoc techniczna
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Pozwól nam pomócSMILES string
FC(F)(F)C(F)(F)C(F)(F)F
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
biological source
human
recombinant
expressed in Pichia pastoris
assay
≥90% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
monomer ~67 kDa
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
human ... ALB(213)
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Ta pozycja | |||
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable | technique(s) tissue culture: suitable | technique(s) ELISA: suitable, tissue culture: suitable, western blot: suitable | technique(s) ELISA: suitable, tissue culture: suitable, western blot: suitable |
| assay ≥90% (agarose gel electrophoresis) | assay ≥96% (agarose gel electrophoresis) | assay ≥99% (agarose gel electrophoresis) | assay - |
| biological source human | biological source human | biological source human | biological source human |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form liquid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
General description
Construct with a single deletion of Asp from the N-terminus to create a hypoallergenic construct. Structural equivalence to native albumin confirmed x-ray crystallography. The Asp deletion eliminates an important antigenic determinant by eliminating the principal copper and nickel binding site of albumin. The first three residues of human albumin are considered non-structural. Also blocked at Cys34 to improve stability, monomer content and homogeneity.
Application
This recombinant variant is recommended for use in absorption, distribution, metabolism, and excretion (ADME) pharmacological research; cell culture; drug delivery research; and cryopreservation of cells.
Biochem/physiol Actions
Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.
Other Notes
View more information on human serum albumin.
Legal Information
Albagen is a trademark of Albumin Therapeutics, LLC.
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Klasa składowania
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hi there, I am looking at the product A7736 recombinant human albumin and I see it is "Albagen™ synonym" according to the description. I know that Albagen has a single deletion N-terminus. So it is not 100% HSA. what about A7736?
1 answer-
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