A7475
Anthopleurin-A trifluoroacetate salt
>88% (HPLC)
Synonim(y):
AP-A trifluoroacetate salt, Anthopleura toxin A trifluoroacetate salt
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C220H326N64O67S6 · xC2HF3O2
Masa cząsteczkowa:
5131.72 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
Assay:
>88% (HPLC)
Form:
solid
Przejdź do
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Pozwól nam pomócassay
>88% (HPLC)
form
solid
storage temp.
−20°C
General description
Synthetic peptide toxin that was originally isolated from the sea anemone, Anthopleura xanthogrammica.
Synthetic peptide toxin.
Application
Anthopleurin-A is a toxin used to study the gating mechanisms of sodium channels. Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel.
Biochem/physiol Actions
Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel.[1] Anthopleurin-A shows a preference towards cardiac channels over the neuronal sodium channels.[2] It is a toxin used to study the gating mechanisms of sodium channels.[1]
Shown to have inotropic effects and not chronotropic effects on mammalian heart preparations.
Other Notes
supplied as trifluoroacetate salt
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Y Pichon
Journal of physiology, Paris, 89(4-6), 171-180 (1995-01-01)
The physiological function of the axon is to conduct short all-or-none action potentials from their site of initiation (usually the cell body) to the synapse. To ensure this function, both passive and active biophysical properties of the axons are tuned
P K Pallaghy et al.
Biochemistry, 34(11), 3782-3794 (1995-03-21)
The three-dimensional structure in aqueous solution of the 49-residue polypeptide anthopleurin-A (AP-A), from the sea anemone Anthopleura xanthogrammica, has been determined from 1H NMR data. A restraint set consisting of 411 interproton distance restraints inferred from NOEs and 19 backbone
Daisuke Izumi et al.
Heart rhythm, 9(5), 796-803 (2011-11-30)
Previous studies have showed that the interval between the peak and the end of the T wave (Tp-e) is a marker of transmural dispersion of ventricular repolarization. We studied the relationship between (a) the Tp-e on local pseudo transmural electrograms
M J Scanlon et al.
Protein science : a publication of the Protein Society, 3(7), 1121-1124 (1994-07-01)
Anthopleurin-A (AP-A) is a member of a family of sea anemone-derived polypeptides that interact with sodium channels in a voltage-dependent manner, producing a positive inotropic effect on the mammalian heart. There has been considerable interest in this molecule as a
S G Priori et al.
Pacing and clinical electrophysiology : PACE, 20(8 Pt 2), 2052-2057 (1997-08-01)
The long QT syndrome (LQTS) is a familial disease characterized by prolonged ventricular repolarization and high incidence of malignant ventricular tachyarrhythmias often occurring in conditions of adrenergic activation. Recently, the genes for the LQTS inked to chromosomes 3 (LQT3), 7
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| A7475-500UG | 04061832960197 |
| A7475-100UG | 04061832960180 |
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