A7230
Alinidine
≥98% (HPLC), solid
Synonim(y):
N-(2,6-Dichlorophenyl)-4,5-dihydro-N-2-propenyl-1H-imidazol-2-amine, ST-567
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C12H13Cl2N3
Numer CAS:
Masa cząsteczkowa:
270.16
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Pomoc techniczna
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Pozwól nam pomócassay
≥98% (HPLC)
form
solid
storage condition
under inert gas
color
off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
Clc1cccc(Cl)c1N(CC=C)C2=NCCN2
Biochem/physiol Actions
Alinidine is an HCN Channel blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels. It is an analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias). Alinidine affects physiological markers in conscious dogs. Alinidine in four intravenous (i.v.) injections of 0.5, 0.5, 1, and 2 mg/kg, decreased sinus rate (< or = 43%) and ventricular rate (< or = 44%), but increased atrial rate (< or = 31%). It lengthened CSRT (< or = 71%) at the two highest doses and increased AERP (< or = 33%) and decreased WP (< or = 33%) at all doses. Alinidine did not modify mean blood pressure at any dose in either group. These results indicate that alinidine exhibits electrophysiologic effects in conscious dogs that reflect the marked antiarrhythmic potential of this agent, apart from its assumed antiischemic properties.
Alinidine is an HCN channel blocker; Blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels. Analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias).
Disclaimer
Air-sensitive
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
J C Preiser et al.
Critical care medicine, 20(8), 1146-1151 (1992-08-01)
Alinidine is a recently developed antiarrhythmic medication that acts directly on the cardiac pacemaker cells to reduce heart rate (HR). At effective doses, alinidine might have cardiodepressant actions that could be hazardous in the presence of hemodynamic instability. On the
J L Challinor-Rogers et al.
Naunyn-Schmiedeberg's archives of pharmacology, 350(2), 158-166 (1994-08-01)
Alinidine, and eight derivatives, were synthesized and tested for their ability to antagonise the actions of the K+ channel opener cromakalim in rat thoracic aorta, and for their ability to induce bradycardia in rat isolated spontaneously beating right atria. Ring
M D Brown et al.
EXS, 61, 389-394 (1992-01-01)
Experiments were performed to test the hypothesis that increased stretch and/or tension of myocytes in the absence of changes in blood flow could induce capillary growth in the heart. Chronic treatment with either dobutamine (rabbits) or alinidine (rats) which increased