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A5879

2-(2-Aminoethyl)isothiourea dihydrobromide

Name: 2-(2-Aminoethyl)isothiourea dihydrobromide
Brand: SIGMA

≥98% (TLC), NOS inhibitor, powder

Synonim(y):

2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide, AET, S-(2-Aminoethyl)isothiouronium bromide hydrobromide

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Informacje o tej pozycji

Wzór liniowy:

NH₂CH₂CH₂SC(=NH)NH₂ · 2HBr

Numer CAS:

56-10-0

Masa cząsteczkowa:

281.01

NACRES:

NA.77

PubChem Substance ID:

24278229

UNSPSC Code:

12352200

EC Number:

200-257-0

MDL number:

MFCD00037011

Beilstein/REAXYS Number:

3911163

Assay:

≥98% (TLC)

Form:

powder

Quality level:

100

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Nazwa produktu

2-(2-Aminoethyl)isothiourea dihydrobromide,

assay

≥98% (TLC)

Quality Level

100

form

powder

mp

190-196 °C (lit.)

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to yellow

SMILES string

Br[H].Br[H].NCCSC(N)=N

InChI

1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H

InChI key

XDVMCVGTDUKDHL-UHFFFAOYSA-N

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Powiązane kategorie

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).

Biochem/physiol Actions

Inhibits constitutive and inducible NOS.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certyfikaty analizy (CoA)

Lot/Batch Number

0000482458

0000429609

0000414166

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Selective inhibition of inducible nitric oxide synthase maintains haemodynamic stability without untoward consequences for hepatic function or morphology.

Y Gundersen et al.

The European journal of surgery = Acta chirurgica, 165(12), 1167-1174 (2000-01-15)

To examine the effects of the inducible nitric oxide synthase inhibitor aminoethyl-isothiourea (AE-ITU) on haemodynamic measurements, and correlate these with hepatic morphology and function in a porcine model of endotoxaemia. Experimental study. 15 juvenile pigs. Flow probes were placed around

Differential effect of 2-aminoethyl-isothiourea, an inhibitor of the inducible nitric oxide synthase, on microvascular blood flow and organ injury in models of hepatic ischemia-reperfusion and endotoxemia.

Y Wang et al.

Shock (Augusta, Ga.), 10(1), 20-25 (1998-08-04)

The vasodilator nitric oxide (NO) is involved in the regulation of systemic blood pressure and local organ blood flow. Inhibitors of the constitutively expressed nitric oxide synthase in endothelial cells (eNOS), e.g., Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME), aggravated liver injury

Polyamines induce rapid biosynthesis of nitric oxide (NO) in Arabidopsis thaliana seedlings.

Ni Ni Tun et al.

Plant & cell physiology, 47(3), 346-354 (2006-01-18)

In this study, we examined the regulation by putrescine, spermidine and spermine of nitric oxide (NO) biosynthesis in Arabidopsis thaliana seedlings. Using a fluorimetric method employing the cell-impermeable NO-binding dye diaminorhodamine-4M (DAR-4M), we observed that the polyamines (PAs) spermidine and

Use of selective and nonselective nitric oxide synthase inhibitors in rat endotoxemia: effects on hepatic morphology and function.

Y Gundersen et al.

Shock (Augusta, Ga.), 8(5), 368-372 (1997-11-15)

Endotoxin has profound effects on nitric oxide (NO) production, and considerable controversies exist as to whether these alterations are beneficial or deleterious. Increased mortality has been reported from nonselective inhibition of NO synthase. Results from selective inhibition of the inducible

Repeated cardiac pacing extends the time during which canine hearts are protected against ischaemia-induced arrhythmias: role of nitric oxide.

A Kis et al.

Journal of molecular and cellular cardiology, 31(6), 1229-1241 (1999-06-18)

Right ventricular pacing in lightly anaesthetized dogs (4x5 min periods at a pacing rate of 220 beats/min) protects against the consequences of coronary artery occlusion when this is initiated 24 h after the pacing stimulus. The main purpose of the

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
A5879-100G	04061833376553
A5879-25G	04061833376560

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