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Merck

A4487

Aphidicolin

Ready Made Solution, from Nigrospora sphaerica

Synonim(y):

ICI 69653, NSC-234714

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1 ML

843,00 zł

843,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C20H34O4
Numer CAS:
38966-21-1
Masa cząsteczkowa:
338.48
UNSPSC Code:
51102829
NACRES:
NA.85
EC Number:
200-664-3
MDL number:
MFCD00083214

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SMILES string

O[C@]1([C@H]2C[C@@]3([C@@]4([C@H]([C@@]([C@@H](CC4)O)(CO)C)CC[C@H]3C2)C)CC1)CO

InChI key

NOFOAYPPHIUXJR-APNQCZIXSA-N

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

biological source

Nigrospora sphaerica

vapor pressure

0.55 hPa ( 20 °C)

Quality Level

200

form

liquid, ready-to-use solution

color

clear colorless

solubility

H2O: miscible (completely)

antibiotic activity spectrum

neoplastics, viruses

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

−20°C

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Ta pozycja
5.04744SML3001SBR00013
Aphidicolin Ready Made Solution, from Nigrospora sphaerica

Sigma-Aldrich

A4487

Aphidicolin

Aphidicolin InSolution, ≥98%, 30 mM in DMSO, A cell-permeable tetracyclic diterpene antibiotic

Sigma-Aldrich

5.04744

Aphidicolin

Phleomycin ready made solution 0.2 μm filtered, 20mg/mL in 20mM HEPES

Sigma-Aldrich

SML3001

Phleomycin ready made solution

Actinomycin D Ready Made Solution, from Streptomyces sp., 2 mg/mL in DMSO

Sigma-Aldrich

SBR00013

Actinomycin D

antibiotic activity spectrum

neoplastics, viruses

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

-

mode of action

-

mode of action

DNA synthesis | interferes

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

form

liquid

form

liquid

form

liquid

form

liquid

solubility

H2O: miscible (completely)

solubility

-

solubility

-

solubility

-

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

General description

Aphidicolin is a tetracyclic diterpene with antiviral and antimitotic properties used for cell cycle synchronization in various cell lines.[1]

Application

Aphidicolin, from Nigrospora sphaerica, was used for cell cycle synchronization of tobacco BY-2 cells. It is used to block the entry of cells into S-phase.[2]

Biochem/physiol Actions

Aphidicolin specifically inhibits DNA polymerase α that is responsible for DNA replication. It also inhibits α-like DNA polymerases of plants and yeasts but does not inhibit synthesis of RNA and proteins. Aphidicolin competes for the dCTP-specific binding site on DNA polymerase α specifically. Aphidicolin has antiviral and antimitotic properties. It blocks the cell cycle at S phase. It has been shown to induce apoptosis in HeLa cells.[3]

Packaging

1 ml

Physical form

Aphidicolin Ready Made Solution supplied as a 1 mg/ml solution in DMSO.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
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Klasa składowania

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

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Certyfikaty analizy (CoA)

Lot/Batch Number
0000529942
0000529942
0000469102
0000469102
0000289532

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Odwiedź Bibliotekę dokumentów

M Oguro et al.
European journal of biochemistry, 97(2), 603-607 (1979-07-01)
The mode of action by aphidicolin on DNA polymerase alpha from the nuclear fraction of sea-urchin blastulae was studied. The inhibition of DNA polymerase alpha by aphidicolin was uncompetive with activated DNA and competitive with the four deoxynucleoside triphosphates using
Anne-Hélène Quélo et al.
Journal of experimental botany, 53(369), 669-675 (2002-03-12)
Endoreduplication is a common process in plants that allows cells to increase their DNA content. In the tobacco cell cultures studied in this work it can be induced by simple hormone deprivation. Mesophyll protoplast-derived cells cultured in the presence of
G Pedrali-Noy et al.
Nucleic acids research, 8(2), 377-387 (1980-01-25)
Both the inhibitory effect of aphidicolin on the replicative alpha-polymerase and the reversibility of its action in vivo (Pedrali-Noy & Spadari, 1979, Biochem. Biophys. Res. Commun. 88, 1194-2002) allow the synchronization of cells in culture. Aphidicolin prevents G1 cells from
K Marheineke et al.
The Journal of biological chemistry, 276(20), 17092-17100 (2001-03-30)
DNA replication origins are located at random with respect to DNA sequence in Xenopus early embryos and on DNA replicated in Xenopus egg extracts. We have recently shown that origins fire throughout the S phase in Xenopus egg extracts. To
Hui Wang et al.
Cancer research, 77(8), 2148-2160 (2017-02-18)
Overexpression of the EVI1 oncogene is associated typically with aggressive myeloid leukemia, but is also detectable in breast carcinoma where its contributions are unexplored. Analyzing a tissue microarray of 608 breast carcinoma patient specimens, we documented EVI1 overexpression in both
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