A271

Anti-α_2A Adrenergic Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonim(y): Anti-ADRA2, Anti-ADRA2R, Anti-ADRAR, Anti-ALPHA2AAR, Anti-ZNF32
• Numer MDL: MFCD01321639
• Kod UNSPSC: 12352203
• NACRES: NA.41
• białko sprzężone: unconjugated
• application: IHC (p); WB
• klon: polyclonal
• reaktywność gatunkowa: rat, human, mouse, pig
• citations: 6
• metody: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1000; western blot: 1:500

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 200
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Formularz: buffered aqueous solution
• masa cząsteczkowa: antigen ~45 kDa
• reaktywność gatunkowa: rat, human, mouse, pig
• metody: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1000; western blot: 1:500
• numer dostępu UniProt: P08913
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... ADRA2A(150) ; mouse ... Adra2a(11551) ; rat ... Adra2a(25083)

Opis

Opis ogólny

Adrenergic receptors (ARs) belong to the 7-transmembrane domain G protein-coupled receptor superfamily that binds to the endogenous catecholamines, epinephrine and norepinephrine. α₂AR subtypes block adenylyl cyclase, suppress voltage-sensitive Ca²⁺ channels, and stimulate receptor dependent K⁺ channels. All of the α₂AR subtypes inhibit adenylyl cyclase through coupling to members of the G_i/G_o class of G proteins. They are an important component of the neural circuitry and modulate cardiovascular physiology. The physiological function of the α₂ARs in the kidney is to regulate Na⁺/H⁺ exchange.
Anti-α_2A adrenergic receptor detects rat and mouse α_2A adrenergic receptors by immunoblotting and immunohistochemistry. In immunoblotting, the antibody detects an approx. 45kDa band representing α_2A receptors in tissues expressing this receptor subtype, although some non-specific bands have also been observed in certain cases.

Immunogen

synthetic peptide derived from amino acids 218-235 of human, mouse, rat, and pig α_2A adrenergic receptor. The immunogen sequence is found within the third intracellular loop of the α_2A adrenergic receptor subtype.

Zastosowanie

Rabbit anti-α_2A adrenergic receptor antibody can be used for western blot (1:500) and immunohistochemistry (1:1000) applications.

Postać fizyczna

Solution in phosphate buffered saline, containing 1 mg/ml BSA and 0.05% sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)