A1388

Adenosine 5′-[γ-thio]triphosphate tetralithium salt

≥75% (HPLC), synthetic (organic), powder

• Synonim(y): ATP-γ-S, Adenosine 5′-(3-thiotriphosphate) tetralithium salt, Ado-5′-PPP[S]
• Wzór empiryczny (zapis Hilla): C₁₀H₁₂Li₄N₅O₁₂P₃S
• Numer CAS: 93839-89-5
• Masa cząsteczkowa: 546.98
• NACRES: NA.51
• PubChem Substance ID: 24890536
• eCl@ss: 32160414
• UNSPSC Code: 41106305
• EC Number: 298-862-8
• MDL number: MFCD00077293
• Beilstein/REAXYS Number: 6265083
• Assay: ≥75% (HPLC)
• Biological source: synthetic (organic)
• Form: powder
• Solubility: H₂O: 25 mg/mL
• Storage temp.: −20°C

Właściwości

• Nazwa produktu: Adenosine 5′-[γ-thio]triphosphate tetralithium salt, ≥75% (HPLC), powder
• InChI key: DWQFDOIBOYDYKH-KWIZKVQNSA-J
• InChI: 1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
• SMILES string: [Li+].[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
• biological source: synthetic (organic)
• assay: ≥75% (HPLC)
• form: powder
• color: off-white
• solubility: H₂O: 25 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• Quality Level: 200

Opis

Application

Adenosine 5′-[γ-thio]triphosphate tetralithium salt has been used to treat the pollen grains to determine the inhibitory effect of adenosine triphosphate (ATP) or its hydrolysis product.[1] It has also been used to select thiophosphorylate target protein.[2]

Biochem/physiol Actions

Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca²⁺-activated K⁺ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death.

Other Notes

Non-hydrolyzable ATP analog

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves