A0401

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

• Synonim(y): ACTH4-10
• Wzór empiryczny (zapis Hilla): C₄₄H₅₉N₁₃O₁₀S
• Numer CAS: 4037-01-8
• Masa cząsteczkowa: 962.09
• UNSPSC Code: 12352202
• PubChem Substance ID: 24890423
• NACRES: NA.26
• MDL number: MFCD00167482

Właściwości

• Nazwa produktu: Adrenocorticotropic Hormone Fragment 4-10 human, rat, ≥97% (HPLC)
• SMILES string: CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O
• InChI: 1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)
• InChI key: HAAUASBAIUJHAN-UHFFFAOYSA-N
• assay: ≥97% (HPLC)
• form: powder
• color: white
• UniProt accession no.: P01189, P47866
• storage temp.: −20°C
• Gene Information: human ... POMC(5443) ; rat ... Crhr2(64680)

Opis

Biochem/physiol Actions

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.

Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

Lacks adrenocorticotropic activity.

Other Notes

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)