A0401

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

• Synonim(y): ACTH4-10
• Wzór empiryczny (zapis Hilla): C₄₄H₅₉N₁₃O₁₀S
• Numer CAS: 4037-01-8
• Masa cząsteczkowa: 962.09
• Numer MDL: MFCD00167482
• Kod UNSPSC: 12352202
• Identyfikator substancji w PubChem: 24890423
• NACRES: NA.26

Właściwości

• product name: Adrenocorticotropic Hormone Fragment 4-10 human, rat, ≥97% (HPLC)
• Próba: ≥97% (HPLC)
• Postać: powder
• kolor: white
• numer dostępu UniProt: P01189; P47866
• temp. przechowywania: −20°C
• ciąg SMILES: CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O
• InChI: 1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)
• Klucz InChI: HAAUASBAIUJHAN-UHFFFAOYSA-N
• informacje o genach: human ... POMC(5443) ; rat ... Crhr2(64680)

Opis

Amino Acid Sequence

Met-Glu-His-Phe-Arg-Trp-Gly

Działania biochem./fizjol.

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.

Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

Inne uwagi

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

Jakość

Lacks adrenocorticotropic activity.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)