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Merck

410R-1

Sigma-Aldrich

Cytokeratin 10 (EP97) Rabbit Monoclonal Primary Antibody

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About This Item

Kod UNSPSC:
12352202
NACRES:
NA.41

pochodzenie biologiczne

rabbit

białko sprzężone

unconjugated

forma przeciwciała

culture supernatant

rodzaj przeciwciała

primary antibodies

klon

EP97, monoclonal

opis

For In Vitro Diagnostic Use in Select Regions (See Chart)

Postać

buffered aqueous solution

reaktywność gatunkowa

human

opakowanie

vial of 0.1 mL concentrate (410R-14)
vial of 0.5 mL concentrate (410R-15)
bottle of 1.0 mL predilute (410R-17)
vial of 1.0 mL concentrate (410R-16)
bottle of 7.0 mL predilute (410R-18)

producent / nazwa handlowa

Cell Marque

metody

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

izotyp

IgG

kontrola

squamous cell carcinoma

Warunki transportu

wet ice

temp. przechowywania

2-8°C

wizualizacja

cytoplasmic

informacje o genach

human ... KRT10(3858)

Opis ogólny

Cytokeratin 10 (CK10) belongs to type I and acidic keratin family. It is low molecular weight keratin that is usually expressed in suprabasal keratinocytes and can also be seen in suprabasal cells of internal noncornifying, stratified squamous epithelia.In addition, CK10 is reported to be a typical component of cells of eccrine sweat gland ducts and sebaceous cells.Anti-CK10 is helpful in the identification of well differentiated squamous cell carcinoma derived from skin or from internal organs.However, CK10 was found to be sparse in poorly differentiated squamous cell carcinoma, even though it has been reported that focal CK10 expression has been found in 50% of cases of oral and pharyngeal squamous cell carcinoma.Anti-CK10 has demonstrated utility in the differentiation of extra-mammary Paget′s disease (negative) from basal cell carcinoma and squamous cell carcinoma (positive).

Jakość


IVD

IVD

IVD

RUO

Powiązanie

Cytokeratin 10 Positive Control Slides, Product No. 410S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Postać fizyczna

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Uwaga dotycząca przygotowania

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Inne uwagi

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informacje prawne

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Roland Moll et al.
Histochemistry and cell biology, 129(6), 705-733 (2008-05-08)
The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed
Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors.
R Moll
Sub-cellular biochemistry, 31, 205-262 (1999-02-05)
Ichiro Kurokawa et al.
Experimental dermatology, 20(3), 217-228 (2011-02-18)
Keratins are a highly diverse family of cytoskeletal proteins and important markers of epithelial cell differentiation. In this review, applying the new keratin nomenclature recently introduced, we summarize and discuss the distribution and significance of keratin patterns in cutaneous epithelial

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