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PHR1173

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N-Acetyl-L-tyrosine

Pharmaceutical Secondary Standard; Certified Reference Material

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1 G
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413,00 zł


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About This Item

Wzór liniowy:
4-(HO)C6H4CH2CH(NHCOCH3)CO2H
Numer CAS:
Masa cząsteczkowa:
223.23
Beilstein:
2697172
Numer WE:
Numer MDL:
Kod UNSPSC:
41116107
eCl@ss:
32160406
Identyfikator substancji w PubChem:
NACRES:
NA.24

413,00 zł


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klasa czystości

certified reference material
pharmaceutical secondary standard

Poziom jakości

agency

traceable to USP 1010106

rodzina API

acetyltyrosine

Certyfikat analizy

current certificate can be downloaded

metody

HPLC: suitable
gas chromatography (GC): suitable

mp

149-152 °C (lit.)

Zastosowanie

pharmaceutical (small molecule)

Format

neat

temp. przechowywania

2-8°C

ciąg SMILES

CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/t10-/m0/s1

Klucz InChI

CAHKINHBCWCHCF-JTQLQIEISA-N

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Opis ogólny

N-Acetyl-L-tyrosine is an acetyl derivative of the amino acid, L-tyrosine. It is freely soluble in water compared to L-tyrosine and is commonly used as a parenteral nutrition supplement.[1]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Zastosowanie

N-Acetyl-L-tyrosine may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by titrimetry[2] and high performance liquid chromatography.[3]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAA6108 in the slot below. This is an example certificate only and may not be the lot that you receive.
Ta strona może zawierać tekst przetłumaczony maszynowo.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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Certyfikaty analizy (CoA)

Lot/Batch Number

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

N-Acetyltyrosine
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 1641-1642 (2017)
N-Acetyltyrosine
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 38(3)(5), 4702-4702 (2018)
Hauh-Jyun Candy Chen et al.
Chembiochem : a European journal of chemical biology, 9(7), 1074-1081 (2008-03-21)
Reactive nitrogen species are implicated in inflammatory diseases and cancers. Oxanine (Oxa) is a DNA lesion product originating from the guanine base through exposure to nitric oxide, nitrous acid, or N-nitrosoindoles. Oxanine was found to mediate formation of DNA-protein cross-links
Michael J Napolitano et al.
Chemical research in toxicology, 18(3), 501-508 (2005-03-22)
The reactions of aqueous ClO2 with tyrosine, N-acetyltyrosine, and dopa (3,4-dihydroxyphenylalanine) are investigated from pH 4 to 7. The reaction rates increase greatly with pH to give a series of oxidized products. Tyrosine and N-acetyltyrosine have similar reactivities with second-order
David I Pattison et al.
Biochemistry, 45(26), 8152-8162 (2006-06-28)
Hypochlorous acid (HOCl) is a powerful oxidant generated from H(2)O(2) and Cl(-) by the heme enzyme myeloperoxidase, which is released from activated leukocytes. HOCl possesses potent antibacterial properties, but excessive production can lead to host tissue damage that is implicated

Questions

  1. Will this ingredient cause a false positive for methamphetamine or amphetamines

    1 answer
    1. If using a validated method, there will not be any false positives for methamphetamine or amphetamines. False positives can occur if doing a R&D assay and using non-validated methods.

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