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B5899

Buflomedil hydrochloride

analytical standard

Synonim(y):

4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C17H25NO4 · HCl
Numer CAS:
35543-24-9
Masa cząsteczkowa:
343.85
NACRES:
NA.24
PubChem Substance ID:
329773268
UNSPSC Code:
41116107
EC Number:
252-611-9
MDL number:
MFCD00078965
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grade

analytical standard

Quality Segment

200

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1

InChI

1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H

InChI key

ZDPACSAHMZADFZ-UHFFFAOYSA-N

Gene Information

human ... EBP(10682)

General description

Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Buflomedil hydrochloride may be used as an analytical standard for the determination of buflomedil in biological matrices using high-performance liquid chromatography technique. It may also be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations and serum samples using electroanalytical and chromatographic techniques.
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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Odwiedź Bibliotekę dokumentów

Claudio Bucolo et al.
Pharmacoepidemiology and drug safety, 21(11), 1190-1196 (2012-08-03)
Review all the individualized cases of adverse drug reaction (ADR) potentially related to buflomedil, a vasodilator with the indication for peripheral arterial disease (PAD), marketed in Europe since the 1970s but recently suspended by the European Medicines Agency. A review
Buflomedil: still too many fatal cardiac and neurological events.
Prescrire international, 20(115), 99-99 (2011-06-09)
Paul P Dobesh et al.
Pharmacotherapy, 29(5), 526-553 (2009-04-29)
Peripheral artery disease, defined as atherosclerosis in the lower extremities, affects nearly 8.5 million people in the United States. Due to the frequent asymptomatic manifestation of peripheral artery disease, diagnosis may be delayed and its true incidence underestimated. However, some
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