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Merck

A3766

Antazoline phosphate salt

analytical standard, for drug analysis

Synonim(y):

2-(N-Benzylanilinomethyl)-2-imidazoline

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Informacje o tej pozycji

Wzór liniowy:
C17H19N3 · H3PO4
Numer CAS:
Masa cząsteczkowa:
363.35
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
205-831-4
MDL number:
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Quality Segment

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

OP(O)(O)=O.C1CN=C(CN(Cc2ccccc2)c3ccccc3)N1

InChI

1S/C17H19N3.H3O4P/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;1-5(2,3)4/h1-10H,11-14H2,(H,18,19);(H3,1,2,3,4)

InChI key

DUIGUKRYYAGJAF-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Imidazoline agonist; more potent than efaroxan in inducing insulin release from β cells; H1 histamine receptor antagonist.
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signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Certyfikaty analizy (CoA)

Lot/Batch Number

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Powiązane treści

Product Information Sheet


D Berdeu et al.
European journal of pharmacology, 324(2-3), 233-239 (1997-04-18)
In vivo effects of an imidazoline devoid of alpha2-adrenoceptor antagonistic properties, antazoline, on insulin secretion and glycemia were investigated both in fasted rats and dogs. In both species, antazoline (1.5 mg/kg i.v.) transiently increased insulinemia without affecting basal plasma glucose
D Berdeu et al.
European journal of pharmacology, 275(1), 91-98 (1995-02-24)
The relative potencies of imidazoline compounds to induce insulin secretion and vascular resistance were compared in the isolated perfused rat pancreas. On insulin secretion, only the two imidazolines, antazoline and efaroxan, induced a concentration-dependent response, antazoline being 10 times more
R Wertheimer et al.
Klinische Monatsblatter fur Augenheilkunde, 210(2), 93-96 (1997-02-01)
Allergic conjunctivitis is one of the most frequent allergic diseases of the anterior eye segment. This multicentre, clinical trial was an investigation to compare the antiallergic efficacy, local tolerance and safety of Antazolin/Tetryzolin eye drops and Levocabastine eye drops. 69