46968
Tolbutamide
VETRANAL®, analytical standard
Synonim(y):
1-Butyl-3-(4-methylphenylsulfonyl)urea, N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C12H18N2O3S
Numer CAS:
Masa cząsteczkowa:
270.35
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-594-3
Beilstein/REAXYS Number:
1984428
MDL number:
Pomoc techniczna
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Pozwól nam pomócgrade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
SMILES string
CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InChI
1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChI key
JLRGJRBPOGGCBT-UHFFFAOYSA-N
Gene Information
human ... ABCC8(6833), KCNJ1(3758), KCNJ11(3767)
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Anti-diabetic agent. Metabolized by CYP2C9 (tolbutamide hydroxylase).
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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Klasa składowania
11 - Combustible Solids
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Genetic factors influencing the metabolism of tolbutamide.
D J Back et al.
Pharmacology & therapeutics, 44(2), 147-155 (1989-01-01)
Kevin S C Hamming et al.
Diabetes, 59(7), 1686-1693 (2010-04-24)
The sodium-calcium exchanger isoform 1 (NCX1) regulates cytoplasmic calcium (Ca(2+)(c)) required for insulin secretion in beta-cells. NCX1 is alternatively spliced, resulting in the expression of splice variants in different tissues such as NCX1.3 and -1.7 in beta-cells. As pharmacological inhibitors
Nico Scheer et al.
Molecular pharmacology, 82(6), 1022-1029 (2012-08-25)
Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 46968-250MG-R | 04061834089483 |