SCC273

C57MG Mouse Mammary Epithelial Cell Line

C57MG mouse mammary epithelial cell line is a useful model system for studies of breast cancer malignancy.

• NACRES: NA.81
• UNSPSC Code: 41106514

Właściwości

• application(s): cell analysis

Opis

General description

Carcinomas arising from epithelial cells lining the mammary glands comprise the overwhelming majority of breast cancer cases (1). Transformation of mammary epithelial cells from their normal non-proliferative condition to an immortal state enabling hyperproliferation and malignancy occurs via bypass of senescence checkpoints. Cellular models that allow study of the mechanisms giving rise to malignancy are of paramount importance to the identification of therapeutic targets for breast cancer treatment.
The C57MG immortalized mammary epithelial cell line is an established model for mammary epithelial malignancy. C57MG cells are syngeneic with the C57BL/6 mouse model and have demonstrated potential of transformation with many proto-oncogenic factors. The C57MG cell line is widely used in studies of the role of Wnt signaling in malignant transformation (4). C57MG cells have been shown to upregulate expression of proto-oncogenic β-catenin in response to Wnt proteins (5). The features of the C57MG cell line make it a highly relevant model system for studies of breast cancer malignancy.

<bold>Source:</bold>
The C57MG cell line was established from mammary epithelial tissue of a C57BL/6 mouse (2).

Research Category:
Cancer

Biochem/physiol Actions

Mouse, Epithelial Cells

Packaging

&ge;1X10⁶ cells/vial

Preparation Note

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/restrictedcelluse. This product may not be: re-engineered or copied; used to make derivatives, modifications or functional equivalents; used to obtain patents or other IP claiming use of the product; used to develop, test, or manufacturer a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact [email protected].

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• wgk: WGK 2