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MABT833

Anti-Galectin-9 Antibody, clone 1G3

clone 1G3, from mouse

Synonim(y):

Galectin-9, Gal-9, Ecalectin, Tumor antigen HOM-HD-21, Galectin-9

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Gabaryty przesyłkiSKUDostępnośćCena netto
100 μg

Przewidywany termin wysyłki07 kwietnia 2026zKuehne + Nagel Sp. z o.o.

1950,00 zł

Informacje o tej pozycji

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
1G3, monoclonal
Application:
ELISA, ICC, IHC, WB
Citations:
-

1950,00 zł


Przewidywany termin wysyłki07 kwietnia 2026Szczegóły


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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

1G3, monoclonal

species reactivity

human

technique(s)

ELISA: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable (paraffin), western blot: suitable

isotype

IgG1κ

NCBI accession no.

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Ta pozycja
G5671MABT51WH0003956M1
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

clone

1G3, monoclonal

clone

VA-11.25, monoclonal

clone

M3/38, monoclonal

clone

1E8-1B2, monoclonal

antibody form

purified antibody

antibody form

purified from hybridoma cell culture

antibody form

purified antibody

antibody form

purified immunoglobulin

Gene Information

human ... LGALS9(3965)

Gene Information

human ... LGALS8(3964)
mouse ... Lgals8(56048)
rat ... Lgals8(116641)

Gene Information

human ... LGALS3(3958)

Gene Information

human ... LGALS1(3956)

biological source

mouse

biological source

mouse

biological source

rat

biological source

mouse

species reactivity

human

species reactivity

mouse, rat, human

species reactivity

mouse, human

species reactivity

human

General description

Galectin-9 (UniProt O00182; also known as Ecalectin, Gal-9, Tumor antigen HOM-HD-21, Urate transporter/channel protein) is encoded by the LGALS9 (also known as HUAT, LGALS9A) gene (Gene ID 3965) in human. The beta-galactoside-binding lectin, Galectin-9, possesses two distinct carbohydrate recognition domains (CRDs) linked together by a peptide domain of different length among the S, M, and L spliced isoforms. Galectin-9 plays a key role in a negative feed-back mechanism against Th1 immune response, where galectin-9 production from various cell types (e.g. fibroblasts and endothelial cells) is induced by interferon-gamma produced by CD4+ Th1 lymphocytes. The up-regulated galectin-9 in turn suppresses CD4+ Th1 lymphocytes, at least in part through stimulation of the Tim-3 receptor. The Tim-3 receptor on CD4+ Th1 cells from patients with multiple sclerosis (MS), rheumatoid arthritis, and auto-immune hepatitis is defective in its response to galectin-9. In addition, excessive galectin-9 production is reported in two human diseases associated with oncogenic viruses, nasopharyngeal carcinomas (NPC) associated with the Epstein-Barr virus (EBV) and chronic infection by the hepatitis C virus (HCV).
~38 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to human Galectin-9.

Application

Immunohistochemistry Analysis: A representative lot detected galectin-9 immunoreactivity in hepatocytes as well as inflammatory leucocytes and Kupffer cells in paraffin-embedded liver sections from patients with hepatitis C or B infection, but not in non-infected liver specimens (Barjon, C., et al. (2012). Infect Agent Cancer. 7(1):16-26).
Immunohistochemistry Analysis: A representative lot detected galectin-9 immunoreactivity in malignant cells using various paraffin-embedded nasopharangeal carcinoma (NPC) tissue sections (Barjon, C., et al. (2012). Infect Agent Cancer. 7(1):16-26).
Western Blotting Analysis: A representative lot detected endogenous galectin-9 isoforms in HeLa, lymphoblastoid cell line (LCL) REMB1, and nasopharyngeal carcinoma (NPC) cell lines C15 & C666-1, as well as exogenously expressed galectin-9 isoforms in transfected HeLa cells, but not in Burkitt’s lymphoma (BL) BL2 cells (Barjon, C., et al. (2012). Infect Agent Cancer. 7(1):16-26).
ELISA Analysis: A representative lot selectively captured human & murine galectin-9 (mGal-9 M, hGAL-9 S & M isoforms), but not human galectin 1, 2, 3, 4, 7, 8, or 10 (Barjon, C., et al. (2012). Infect Agent Cancer. 7(1):16-26).
Immunocytochemistry Analysis: A representative lot detected galectin-9 immunoreactivity in formalin-fixed and paraffin-embedded lymphoblastoid cell line (LCL) REMB1, but not in Burkitt’s lymphoma (BL) BL2 cells (Barjon, C., et al. (2012). Infect Agent Cancer. 7(1):16-26).
This Anti-Galectin-9 Antibody, clone 1G3 is validated for use in Western Blotting, Immunohistochemistry (Paraffin), ELISA and Immunocytochemistry for the detection of Galectin-9.

Biochem/physiol Actions

Clone 1G3 reacts with all three (L, M, and S) galectin-9 isoforms, but not galectin 1, 2, 3, 4, 7, 8, or 10.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in HeLa nuclear extract.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Galectin-9 in 10 µg of HeLa nuclear extract.

Other Notes

Concentration: Please refer to lot specific datasheet.
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Klasa składowania

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Numer pozycji handlu globalnego

SKUNUMER GTIN
MABT83304055977288438

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