MABN2395

Anti-Peripherin-2 Antibody, clone 2B7

clone 2B7, from mouse

• Synonim(y): Retinal degeneration slow protein
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 100
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: 2B7, monoclonal
• reaktywność gatunkowa: mouse, bovine
• metody: immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable (paraffin); western blot: suitable
• izotyp: IgG1κ
• numer dostępu NCBI: NP_032964.1
• numer dostępu UniProt: P15499
• Warunki transportu: ambient
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: mouse ... Prph2(19133)

Opis

Opis ogólny

Peripherin-2 (UniProt: P15499; also known as Retinal degeneration slow protein) is encoded by the Prph2 (also known as Rds) gene (Gene ID: 19133) in murine species. Peripherin-2 is a multi-pass membrane glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It is localized to the photoreceptor disc rim region and is required for the initial formation and subsequent maintenance of both rod and cone outer segments. It can function as an adhesion molecule for stabilization and compaction of outer segment disks and the maintenance of the curvature of the rim. Mutations Prph2 gene are reported to cause incurable retinal degeneration. Peripherin-2 can form a wide variety of covalent and non-covalent homo- and heteromeric complexes and failure to oligomerize properly can result in protein degradation and retinitis pigmentosa.

Specyficzność

Clone 2B7 detects peripherin-2 in murine and bovine eye. It targets an epitope within 23 amino acids from the C-terminal end.

Immunogen

KLH-conjugated linear peptide corresponding to 23 amino acids from the C-terminal region of murine Peripherin-2.

Zastosowanie

Anti-Peripherin-2, clone 2B7, Cat. No. MABN2395, is a highly specific mouse monoclonal antibody that targets Peripherin-2/RDS and has been tested in Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), and Western Blotting.

Western Blotting Analysis: A representative lot detected Peripherin-2 in Western Blotting applications (Stuck, M.W., et. al. (2014). Hum Mol Genet. 23(23):6260-74).

Immunofluorescence Analysis: A representative lot detected Peripherin-2 in Immunofluorescence applications (Chakraborty, D., et. al. (2010). Hum Mol Genet. 19(24):4799-812).

Western Blotting Analysis: A representative lot detected Peripherin-2 in Western Blotting applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).

Immunocytochemistry Analysis: A representative lot detected Peripherin-2 in Immunocytochemistry applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).

Jakość

Evaluated by Immunohistochemistry in the outer layer of photoreceptor cells of mouse eye tissue.

Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Peripherin-2 in the outer layer of photoreceptor cells of mouse eye tissue.

Opis wartości docelowych

39.26 kDa calculated.

Postać fizyczna

Format: Purified

Inne uwagi

Concentration: Please refer to lot specific datasheet.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1