The capture antibody is monoclonal mouse anti-Human MMP-9, which does not react with the C-terminal truncated form. The detection antibody is polyclonal Goat anti-human MMP-9.
HMMP2MAG-55K
MILLIPLEX® Human MMP Magnetic Bead Panel 2 - Immunology Multiplex Assay
Matrix Metalloproteinase Bead-Based Multiplex Assays using the Luminex technology enable the simultaneous analysis of multiple MMPs biomarkers in human serum, plasma and cell culture samples.
Synonim(y):
10549 Ludzki test immunologiczny MMP, Panel ludzkich MMP Millipore, Zestaw multipleksowy ludzkiej metaloproteinazy macierzy
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About This Item
Kod UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.84
To order a Milliplex® kit, please search for your analyte of interest.
Polecane produkty
Poziom jakości
reaktywność gatunkowa
human
producent / nazwa handlowa
Milliplex®
assay range
accuracy: 72-98%
standard curve range: 14-10,000 pg/mL
(MMP-9)
standard curve range: 27-20,000 pg/mL
(MMP-1)
standard curve range: 27-20,000 pg/mL
(MMP-10)
standard curve range: 548-400,000 pg/mL
(MMP-7)
standard curve range: 68-50,000 pg/mL
(MMP-2)
metody
multiplexing: suitable
metoda wykrywania
fluorometric (Luminex xMAP)
Warunki transportu
wet ice
Opis ogólny
MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in arthritis, cardiovascular disease and tumor growth and metastasis.
MMP/TIMP research plays a significant role in achieving a deeper understanding of disease states such as chronic inflammation, cardiovascular disease, and cancer.
The MILLIPLEX® Human MMP Bead Panel 2 (MMP-1, -2, -7, -9, -10) will enable you to explore the modulation of and the function of MMP expression in multiple therapeutic areas.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cytokines/Chemokines
MMP/TIMP research plays a significant role in achieving a deeper understanding of disease states such as chronic inflammation, cardiovascular disease, and cancer.
The MILLIPLEX® Human MMP Bead Panel 2 (MMP-1, -2, -7, -9, -10) will enable you to explore the modulation of and the function of MMP expression in multiple therapeutic areas.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cytokines/Chemokines
Specyficzność
Cross Reactivty
No significant cross-reactivity was observed among analytes in this panel.
No significant cross-reactivity was observed among analytes in this panel.
Zastosowanie
- Analytes: MMP-1, MMP-2, MMP-7, MMP-9, MMP-10
- Recommended Sample type: human serum, plasma, tissue/cell lystate and culture supernatant samples
- Recommended Sample dilution: 1:20
- Assay Run Time: One day
- Research Category: Inflammation & Immunology
Cechy i korzyści
Design your multiplex kit by choosing available analytes within this panel.
Przechowywanie i stabilność
Recommended storage for kit components is 2 - 8°C.
Inne uwagi
Sensitivity: See protocol for sensitivities of individual analytes.
Informacje prawne
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
Organy docelowe
Respiratory Tract
Kod klasy składowania
10 - Combustible liquids
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Yu Yue et al.
BioMed research international, 2020, 2961742-2961742 (2020-07-01)
The present study investigated the profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) of the aqueous humor (AH) and plasma (PL) in myopia patients, to determine whether there was an association between these levels with their axial
Livia V Souza et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 30(1), 60-70 (2019-11-23)
The purpose of this study was to investigate whether an intervention with physical activity (PA) would promote positive effects on the angiogenic factors, mobilization, and functionality of circulating endothelial progenitor cells (EPCs) in children with low birth weight (LBW). Thirty-five
Mittal Jasoliya et al.
Brain sciences, 10(6) (2020-06-14)
Recent advances in neurobiology have provided several molecular entrees for targeted treatments for Fragile X syndrome (FXS). However, the efficacy of these treatments has been demonstrated mainly in animal models and has not been consistently predictive of targeted drugs' response
Ulrike Müller et al.
Mediators of inflammation, 2015, 626530-626530 (2015-07-18)
In cystic fibrosis (CF) the upper (UAW) and lower airways (LAW) are reservoirs for pathogens like Pseudomonas aeruginosa. The consecutive hosts' release of proteolytic enzymes contributes to inflammation and progressive pulmonary destruction. Objectives were to assess dynamics of protease :
Larissa Berloffa Belardin et al.
Scientific reports, 9(1), 903-903 (2019-01-31)
Matrix Metalloproteinases (MMPs) and their regulators - Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) - participate in extracellular matrix remodeling, fibrosis, and semen liquefaction, as well as to inflammatory activity. Seminal plasma has been shown to contain MMPs (MMP-2 and MMP-9)
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Uprość odkrywanie biomarkerów białkowych dzięki multipleksowemu panelowi przesiewowemu MILLIPLEX® PLEXpedition 115-Plex. Bez wysiłku badaj cytokiny i inne markery dzięki technologii Luminex®.
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Wykrywanie biomarkerów nowotworowych za pomocą multipleksowych testów nowotworowych MILLIPLEX® może przyspieszyć badania procesów nowotworowych, pomagając w rozwoju badań nad rakiem.
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Can you provide information on the Human MMP-9 Milliplex assay? Specifically, does the assay detect both Pro-MMP9 and Active MMP9 or only the latter?
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