ABS986

Anti-PCTP Antibody

serum, from rabbit

• Synonim(y): Phosphatidylcholine transfer protein, PC-TP, START domain-containing protein 2, StARD2, StAR-related lipid transfer protein 2
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: serum
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• reaktywność gatunkowa: human, mouse
• metody: immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• numer dostępu NCBI: NP_067036
• numer dostępu UniProt: Q9UKL6
• Warunki transportu: dry ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... PCTP(58488)

Opis

Opis ogólny

Phosphatidylcholine transfer protein (PCTP), also known as PC-TP, START domain-containing protein 2, StARD2, StAR-related lipid transfer protein 2, and encoded by the gene symbol PCTP/ STARD2, belongs to the steroidogenic acute regulatory protein related transfer (START) domain superfamily of hydrophobic ligand-binding proteins. PCTP has been shown to play an important role in the transfer of phosphatidylcholine between membranes. The crystal structures of human PC-TP in complex with dilinoleoyl-PtdCho or palmitoyl-linoleoyl-PtdCho suggests that a single well-ordered PtdCho molecule occupies a centrally located tunnel. These structures have provided a basis for rationalizing the specificity of PC-TP for PtdCho and may identify common features used by START proteins to bind their hydrophobic ligands. Additionally, PCTP has been demonstrated to interact with ACOT13/THEM2. PCTP is located in the cytoplasm with highest expression in liver, placenta, testis, kidney and heart. Low levels of PCTP are expressed in brain and lung.

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of human PCTP.

Zastosowanie

Anti-PCTP is an antibody against PCTP for use in WB, ICC, IP.

Western Blotting Analysis: A representative lot detected PCTP in cytosolic fractions isolated from the liver of a control subject, a patient with intrahepatic brown pigment stones, and a patient with obstructive cholestasis (Shoda, J., et al. (2001). Hepatology. 33(5):1194-1205).
Western Blotting Analysis: A representative lot detected PCTP in siRNA-transfected, serum-starved HEK 293E cells, Pctp+/+ liver lysates, Tsc2−/− MEFs, Liver homogenates from chow diet–fed Pctp+/+ (n = 4) and Pctp−/− (n = 4) mice (Ersoy, B.A., et al. (2013). Science Signaling. 286(6):1-11).
Immunocytochemistry Analysis: A representative lot detected PCTP in HEK293T cells (Kanno, K., et al. (2007). J. Biol. Chem. 282:30728-30736).
Immunoprecipitation Analysis: A representative lot immunoprecipitated PCTP in Pctp+/+ liver lysates (Ersoy, B.A., et al. (2013). Science Signaling. 286(6):1-11).

Jakość

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected PCTP in 5 µg of HepG2 cell lysate.

Opis wartości docelowych

~33 kDa observed

Inne uwagi

Concentration: Please refer to lot specific datasheet.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1