ABS764

Anti-GPAT-1 Antibody

from rabbit, purified by affinity chromatography

• Synonim(y): Glycerol-3-phosphate acyltransferase 1, mitochondrial, GPAT-1
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702

Właściwości

• Nazwa produktu: Anti-GPAT-1 Antibody, from rabbit, purified by affinity chromatography
• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: rat
• technique(s): immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• UniProt accession no.: Q9HCL2
• shipped in: wet ice
• target post-translational modification: unmodified
• Quality Level: 100
• Gene Information: human ... GPAM(57678)

Opis

Analysis Note

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected GPAT-1 in rat brain tissue lysate.

Application

Anti-GPAT-1 Antibody is an antibody against GPAT-1 for use in western blotting, IHC & immunofluorescence.

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected GPAT-1 in rat brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected GPAT-1 in rat brain cells.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT-1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT-1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT-1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT-1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets.

~82 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Immunogen

Epitope: C-terminus

KLH-conjugated synthetic peptide corresponding to the C-terminus of human GPAT-1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: MABS402

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable