ABS543

Anti-Colipase Antibody

serum, from rabbit

• Synonim(y): Colipase
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: serum
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• reaktywność gatunkowa: mouse
• metody: western blot: suitable
• numer dostępu NCBI: NP_001823
• numer dostępu UniProt: P04118
• Warunki transportu: dry ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... CLPS(1208)

Opis

Opis ogólny

The protein Colipase is a co-enzyme needed for maximal enzyme activity of pancreatic lipase. It is a secreted protein produced by the pancreas that is originally secreted as an inactive proform, procolipase. Procolipase gets activated by cleavage by intestinal trypsin in the lumen of the small intestine. Once activated, Colipase′s function is to help overcome the inhibitory effect of bile salts on the lipase catalyzed hydrolysis of long-chain triglycerides that needs to occur within the duodenum. Colipase happens to have key hydrophobic amino acids that allow the complex of lipase and Colipase to adsorb to the lipid micelles, and this adsorption is essential for their digestion. Interestingly too, the procolipase propeptide also gives rise to the pentapeptide intestinal hormone Enterostatin, a small pentapeptide. Enterostatin acts to reduce food intake, in particular fat intake, when given to animals via injection or in to the brain.

Immunogen

Epitope: Unknown

Recombinant protein corresponding to human Colipase.

Zastosowanie

Anti-Colipase Antibody | ABS543 is an antibody against Colipase Antibody for use in Western Blotting.

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

Western Blotting Analysis: A representative lot detected Colipase in purified protein (D′Silva, S., et al. (2007). Journal of Lipid Research. 48:2478-2484).
Western Blotting Analysis: A representative lot detected Colipase in mouse pancreas (Miller, R., et al. (2009). AM J Physiol Endocrinol Metab. 297:E856-E865).
Western Blotting Analysis: A representative lot detected Colipase in HEK293T cells transiently transfected to express Arg92 and Cys92 colipase (Xiao, X., et al. (2013). Journal of Lipid Research. 54:514-521).

Jakość

Evaluated by Western Blotting in mouse pancreas tissue lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Colipase in mouse pancreas tissue lysate.

Opis wartości docelowych

~12 kDa observed

Postać fizyczna

Rabbit polyclonal serum with 0.05% sodium azide.

Unpurified

Przechowywanie i stabilność

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Inne uwagi

Concentration: Please refer to lot specific datasheet.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1