ABF29

Anti-NLRP6 (NALP6) Antibody

from rabbit, purified by affinity chromatography

• Synonim(y): NACHT, PYRIN-containing APAF1-like protein 5, LRR and PYD domains-containing protein 6
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702

Właściwości

• Nazwa produktu: Anti-NLRP6 (NALP6) Antibody, from rabbit, purified by affinity chromatography
• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: rat, human
• species reactivity (predicted by homology): rhesus macaque (based on 100% sequence homology)
• technique(s): immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI accession no.: NP_612202
• UniProt accession no.: P59044
• shipped in: wet ice
• target post-translational modification: unmodified
• Quality Level: 100
• Gene Information: human ... NLRP6(171389)

Opis

Analysis Note

Control
Rat basophilic leukemia (RBL) cell lysate

Evaluated by Western Blot in rat basophilic leukemia (RBL) cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected NLRP6 (NALP6) in 10 µg of rat basophilic leukemia (RBL) cell lysate.

Application

Anti-NLRP6 (NALP6) Antibody detects level of NLRP6 (NALP6) & has been published & validated for use in WB, IH(P).

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected NLRP6 (NALP6) in epithelial tissue of proximal and distal tubules of human kidney, and in human bone marrow tissue.

Biochem/physiol Actions

Other homologies: Mouse (93% sequence homology).

This antibody recognizes the NACHT domain of NLRP6 (NALP6).

General description

NRLP6 (NALP6) (also known as PYRIN-containing Apaf-1-like protein 5 or PYPAF5) belongs to a family of proteins that play a critical role in apoptosis and in inflammatory signaling. Its expression is highly restricted to granulocytes and T-cells. Co-expression of NALP6 with ASC results in synergistic activation of caspase-1-dependent cytokine processing, subsequent NF-kB activation, and downstream recruitment of PYPAF5 to punctate structures in the cytoplasm. Overlapping genes in NALP6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR.

~99 kDa observed

Immunogen

Epitope: NACHT domain

Linear peptide corresponding to NACHT domain of human NLRP6 (NALP6).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable