AB3098
Anti-Orexin-A Antibody
Chemicon®, from rabbit
Synonim(y):
Anti-NRCLP1, Anti-OX, Anti-PPOX
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
forma przeciwciała
affinity purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
polyclonal
oczyszczone przez
affinity chromatography
reaktywność gatunkowa
feline, rat, human, mouse
producent / nazwa handlowa
Chemicon®
metody
ELISA: suitable
western blot: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... PPOX(5498)
Specyficzność
Mouse Orexin-A. Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus (Sakurai et al. 1998). Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is an 130 aa peptide with a putative 33 aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis (Sakurai et al. 1998). These neuropeptides bind and activate two closely related Orexin receptors--G protein coupled receptors (GPCRs) OX1R and OX2R.
Immunogen
An 18 amino acid peptide mapping near the amino terminus of mouse Orexin-A. The immunogen sequence is identical in human, rat, porcine, ovine, bovine and canine and has 81% homology with chicken.
Zastosowanie
Research Category
Neuroscience
Neuroscience
Research Sub Category
CNS Control of Metabolism
Circadian Rhythm & Sleep
CNS Control of Metabolism
Circadian Rhythm & Sleep
This Anti-Orexin-A Antibody is validated for use in ELISA, WB for the detection of Orexin-A.
Western blot: 1-10 μg/mL using Chemiluminescence technique ELISA: 1:10,000 - 100,000 using 5-100 ng of control peptide per well. NOTE: Orexin A is a 3.5kDa protein. Adjust your SDS-PAGE gel and lane size markers accordingly.
Immunohistochemistry: Frozen 4% PFA tissue with ABC detection {Wagner et al 2000}.
Optimal working dilutions must be determined by end user.
Immunohistochemistry: Frozen 4% PFA tissue with ABC detection {Wagner et al 2000}.
Optimal working dilutions must be determined by end user.
Postać fizyczna
Liquid in PBS, pH 7.4 with 0.1% BSA and 0.1% sodium azide.
Przechowywanie i stabilność
Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Hypothalamus-olfactory system crosstalk: orexin a immunostaining in mice.
Gascuel, J; Lemoine, A; Rigault, C; Datiche, F; Benani, A; Penicaud, L; Lopez-Mascaraque, L
Frontiers in Neuroanatomy null
Hyunjin Shin et al.
Scientific reports, 13(1), 20245-20245 (2023-11-21)
It has been suggested that stress responses induced by fasting have analgesic effects on nociception by elevating the levels of stress-related hormones, while there is limited understanding of pain control mechanisms. Here, we investigated whether acute or intermittent fasting alleviates
Organization and number of orexinergic neurons in the hypothalamus of two species of Cetartiodactyla: a comparison of giraffe (Giraffa camelopardalis) and harbour porpoise (Phocoena phocoena).
Dell, LA; Patzke, N; Bhagwandin, A; Bux, F; Fuxe, K; Barber, G; Siegel, JM; Manger, PR
Journal of Chemical Neuroanatomy null
S Schreyer et al.
Neuroscience, 164(2), 629-640 (2009-08-26)
Orexin-A, synthesized by neurons of the lateral hypothalamus helps to maintain wakefulness through excitatory projections to nuclei involved in arousal. Obvious changes in eye movements, eyelid position and pupil reactions seen in the transition to sleep led to the investigation
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