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AB2233

Sigma-Aldrich

Anti-Galanin Antibody

serum, from rabbit

Synonim(y):

galanin prepropeptide, galanin-message-associated peptide, galanin-related peptide

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

forma przeciwciała

serum

rodzaj przeciwciała

primary antibodies

klon

polyclonal

reaktywność gatunkowa

rat

reaktywność gatunkowa (przewidywana na podstawie homologii)

mouse, boar, human

metody

immunohistochemistry: suitable (paraffin)

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... GAL(51083)

Opis ogólny

Galanin is a neuropeptide which is not a member of any known family of neuropeptides, despite repeated efforts to discover related peptides. Its actions are mediated via Gi-protein-coupled receptors (GPCR’s) and ion channels, usually producing inhibition of secretion of a transmitter or hormone in the nervous and endocrine system. In many respects, these inhibitory actions of galanin remind us of those of gamma-aminobutyric acid (GABA) and of neuropeptide Y (NPY). Galanin coexists with GABA, noradrenaline, 5-hydroxytryptamine (5-HT), and NPY in several regions of the brain. Galanin and it’s receptor are over expressed in limbic region of the brain in patients suffering from Alzheimer′s disease. However it is not clear whether galanin exacerbates or is a protective response to the disease.

Specyficzność

Cat. # AB2233 recognizes Galanin
Reactivity with other species has not been determined.

Immunogen

Synthetic Linear Peptide

Zastosowanie

Detect Galanin using this Anti-Galanin Antibody validated for use in IH(P).
Research Category
Neuroscience
Research Sub Category
Neurochemistry & Neurotrophins

Jakość

Routinely evaluated by Immunhistochemistry on rat cerebellum tissue.

Opis wartości docelowych

13.3 kDa

Postać fizyczna

Serum with 0.05% NaN3

Przechowywanie i stabilność

Maintain at -20°C for up to 1 year from date of receipt.

Komentarz do analizy

Control
Rat Cerebellum Tissue

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1


Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Liliana Rytel et al.
Anatomia, histologia, embryologia, 47(6), 517-526 (2018-08-15)
The gastrointestinal (GI) tract is innervated by nerve processes derived from the intramural enteric neurons and neurons localized outside the digestive tract. This study analysed the neurochemical characterization of nerves in the wall of the porcine oesophagus using single immunofluorescence
Kamila Szymanska et al.
International journal of molecular sciences, 19(3) (2018-03-21)
Bisphenol A, used in the production of plastic, is able to leach from containers into food and cause multidirectional adverse effects in living organisms, including neurodegeneration and metabolic disorders. Knowledge of the impact of BPA on enteric neurons is practically
Yutaro Komuro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(42), 8725-8741 (2021-09-01)
Galanin, one of the most inducible neuropeptides, is widely present in developing brains, and its expression is altered by pathologic events (e.g., epilepsy, ischemia, and axotomy). The roles of galanin in brain development under both normal and pathologic conditions have
Krystyna Makowska et al.
Animals : an open access journal from MDPI, 10(12) (2021-01-10)
Bisphenol A (BPA) is widely utilized in plastic production process all over the world. Previous studies have shown that BPA, with its similarity to estrogen, may negatively affect living organisms. It is acknowledged that BPA distorts the activity of multiple
Joanna L Elson et al.
Neurotoxicity research, 34(1), 16-31 (2017-12-09)
Parkinson's disease (PD) is conventionally seen as resulting from single-system neurodegeneration affecting nigrostriatal dopaminergic neurons. However, accumulating evidence indicates multi-system degeneration and neurotransmitter deficiencies, including cholinergic neurons which degenerate in a brainstem nucleus, the pedunculopontine nucleus (PPN), resulting in motor

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