AB2201

Anti-mPER1 (residues 6-21) Antibody

serum, from rabbit

• Synonim(y): Circadian clock protein PERIOD 1, Circadian pacemaker protein Rigui, Period, drosophila, homolog of period 1, period (Drosophila) homolog 1, period homolog 1 (Drosophila)
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 18

Właściwości

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: serum
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: human, mouse, rat
• technique(s): western blot: suitable
• GenBank accession no.: BAA94086
• UniProt accession no.: O35973
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: mouse ... Per1(18626)

Opis

General description

136 kDa

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.

Application

Detect mPER1 (residues 6-21) using this Anti-mPER1 (residues 6-21) Antibody validated for use in WB.

Immunohistichemistry:
Tested on whole brain (SCN; peak staining at CT/ZT12). Optimium working dilutions need to be determined by end used.

Biochem/physiol Actions

Cat. # AB2201 will recognize the N-terminus of mPER1.

May react with Drosophila, Arvicanthis niloticus and Mesocricetus auratus based on sequence homology. Reactivity with other species has not been tested.

Analysis Note

Routinely tested by western blot on human brain lysate

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