616467 Sigma-Aldrich Transglutaminase 2 Inhibitor, ZDON has not been validated in house in a Western Blotting application. It is a cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150 nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2.
This information is derived from the publication referenced on the MilliporeSigma website:
McConoughey, S. J., et al. 2010. EMBO Mol. Medicine. 2, 349.
616467
ZDON
≥98% (HPLC), powder, transglutaminase 2 inhibitor, Calbiochem®
Synonim(y):
Transglutaminase 2 Inhibitor, ZDON, Z-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
5 mg | Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o. | 1260,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C31H45N7O9
Masa cząsteczkowa:
659.73
UNSPSC Code:
12352200
NACRES:
NA.54
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze
1260,00 zł
Dostępne do wysyłki DZISIAJSzczegóły
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Pozwól nam pomócNazwa produktu
Transglutaminase 2 Inhibitor, ZDON, A cell-permeable, peptide-based, irreversible inhibitor of transglutaminase 2 (TG2; IC50 = 150 nM for recombinant TG2). Reacts with the active site cysteine of TG2.
Quality Segment
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150 nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (~50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
McConoughey, S. J., et al. 2010. EMBO Mol. Medicine.2, 349.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Ta pozycja | |||
|---|---|---|---|
| description A cell-permeable, peptide-based, irreversible inhibitor of transglutaminase 2 (TG2; IC50 = 150 nM for recombinant TG2). Reacts with the active site cysteine of TG2. | description - | description The JNK Inhibitor XIII, also referenced under CAS 40045-50-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. | description The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| form powder | form powder | form solid | form solid |
| assay ≥98% (HPLC) | assay ≥99% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| storage condition OK to freeze | storage condition OK to freeze, protect from light | storage condition protect from light, OK to freeze | storage condition OK to freeze, desiccated (hygroscopic), protect from light |
Klasa składowania
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Do you have any validations for Western blot showing that the provided ZDON lowers the TGM2 proteins levels? How have you validated TGM2 activity inhibition by ZDON if not by Western blot?
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