528120

PIPER - CAS 213416-70-7 - Calbiochem

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA.

• Synonim(y): PIPER - CAS 213416-70-7 - Calbiochem, N,Nʹ- bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV, N,Nʹ-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV
• Wzór empiryczny (zapis Hilla): C₃₈H₃₆N₄O₄
• Numer CAS: 213416-70-7
• Masa cząsteczkowa: 612.72
• Kod UNSPSC: 12352200

Właściwości

• Próba: ≥95% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: dark purple
• rozpuszczalność: 5% acetic acid: 50 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: −20°C

Opis

Opis ogólny

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May also be useful as an antiproliferative agent.

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May be useful as an antiproliferative agent.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
human telomerase

Product does not compete with ATP.

Reversible: no

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Inne uwagi

Han, H., et al. 1999. Biochemistry38, 6981.
Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable