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Merck

472804

S-Methyl-L-thiocitrulline, Dihydrochloride

A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM).

Synonim(y):

S-Methyl-L-thiocitrulline, Dihydrochloride, N δ-(S-Methyl)isothioureido-L-ornithine, Nδ-(S-Methyl)isothioureido-L-ornithine

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C7H15N3O2S · 2HCl
Numer CAS:
Masa cząsteczkowa:
278.20
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
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Quality Level

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white to off-white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

S(C)\C(=N/CCC[C@H]([N+H3])C(=O)[O-])\N

InChI

1S/C7H15N3O2S/c1-13-7(9)10-4-2-3-5(8)6(11)12/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12)/t5-/m0/s1

InChI key

NGVMVBQRKZPFLB-YFKPBYRVSA-N

General description

A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM).
A cell-permeable, inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM).

Biochem/physiol Actions

Reversible: no
Target IC50: 300 nM for rat neuronal nitric oxide synthase
Cell permeable: yes
Primary Target
Rat neuronal nitric oxide synthase
Product does not compete with ATP.

Packaging

Packaged under inert gas

Other Notes

Krishnaswamy, N., et al. 1995. J. Biol. Chem.270, 11103.
Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.
Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem.37, 885.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)
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Klasa składowania

11 - Combustible Solids

wgk

WGK 3


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M Marquina et al.
The British journal of dermatology, 159(1), 68-76 (2008-05-15)
Pemphigus vulgaris (PV) is a blistering autoimmune disease characterized by IgG autoantibodies against desmoglein 3. Nitric oxide synthases (NOS) may contribute to the increase of inflammation in tissues by the generation of nitrotyrosine residues (NTR). To investigate whether the production

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Numer pozycji handlu globalnego

SKUNUMER GTIN
472804-10MG04055977185331

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