444285

MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem

The MMP-2/MMP-9 Inhibitor V, also referenced under CAS 869577-53-7, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonim(y): MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem, (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS
• Wzór empiryczny (zapis Hilla): C₁₆H₁₇NO₅S₃
• Numer CAS: 869577-53-7
• Masa cząsteczkowa: 399.50
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥85% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: white
• rozpuszczalność: DMSO: 200 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: −20°C

Opis

Opis ogólny

A cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (K_i = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (K_i = 3.6 µM, 295 µM, and >25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and >25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.

Działania biochem./fizjol.

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Target K_i: 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Inne uwagi

Ikejiri, M., et al. 2005. J. Biol. Chem.280, 33992.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10-13 - German Storage Class 10 to 13