420135

JNK Inhibitor VIII

The JNK Inhibitor VIII, also referenced under CAS 894804-07-0, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonim(y): JNK Inhibitor VIII, N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
• Wzór empiryczny (zapis Hilla): C₁₈H₂₀N₄O₄
• Numer CAS: 894804-07-0
• Masa cząsteczkowa: 356.38
• MDL number: MFCD19690908
• UNSPSC Code: 41116133
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: brown
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: N(c2nc(c(c(c2)N)C#N)OCC)C(=O)Cc1c(ccc(c1)OC)OC
• InChI: 1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
• InChI key: KQMPRSZTUSSXND-UHFFFAOYSA-N

Opis

General description

A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (K_i = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC₅₀ of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target K_i: 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively

Packaging

Packaged under inert gas

Other Notes

Vivanco, I., et al. 2007. Cancer Cell11, 555.
Szczepankiewicz, B. G., et al. 2006. J. Med. Chem.49, 3563.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable