371708

Gβγ Modulator II, Gallein

A cell-permeable xanthene compound that binds to Gβγ with high affinity (K_d ~400 nM derived from a surface plasma resonance binding study using Gβ1γ2) and blocks Gβγ-dependent cellular activities.

• Synonim(y): Gβγ Modulator II, Gallein, 4,5-Dihydroxyfluorescein, dihydrate, 2-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)-benzoic acid, dihydrate
• Wzór empiryczny (zapis Hilla): C₂₀H₁₂O₇ · 2H₂O
• Numer CAS: 2103-64-2
• Masa cząsteczkowa: 400.34
• MDL number: MFCD00041839
• UNSPSC Code: 12171500
• NACRES: NA.77
• Assay: ≥90% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: burgundy
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O1C3(c4c(c(c(cc4)O)O)Oc5c3ccc(c5O)O)c2c(cccc2)C1=O
• InChI: 1S/C20H12O7/c21-13-7-5-11-17(15(13)23)26-18-12(6-8-14(22)16(18)24)20(11)10-4-2-1-3-9(10)19(25)27-20/h1-8,21-24H
• InChI key: PHLYOKFVXIVOJC-UHFFFAOYSA-N

Opis

General description

A cell-permeable xanthene compound that binds to Gβγ with high affinity (K_d ~400 nM derived from a surface plasma resonance binding study using Gβ₁γ₂) and blocks Gβγ-dependent cellular activities. Reported to exhibit in vivo prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model via either intraperitoneal or oral administration.

Packaging

Packaged under inert gas

Other Notes

Lehmann, D.M., et al. 2008. Mol. Pharmacol.73, 410.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable