344281-M

Forskolin, NKH477

A cell-permeable and water-soluble Forskolin derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC.

• Synonim(y): Forskolin, NKH477, 6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
• Wzór empiryczny (zapis Hilla): C₂₇H₄₃NO₈ · xHCl
• Numer CAS: 138605-00-2
• Masa cząsteczkowa: 509.63 (free base basis)
• Numer MDL: MFCD00236421
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥97% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated (hygroscopic); protect from light
• kolor: white
• rozpuszczalność: water: 10 mg/mL
• temp. przechowywania: 2-8°C
• InChI: 1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
• Klucz InChI: VIRRLEDAYYYTOD-YHEOSNBFSA-N

Opis

Opis ogólny

A cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.

A cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.

Ostrzeżenie

Toxicity: Highly Toxic (H)

Inne uwagi

Nakashima, S., et al. 2005. J. Heart Lung Transplant.24, 462.
Morinobu, S., et al. 1999. J. Neurochem.72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol.123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol.30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev.13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol.19, 625.
Shafiq, J., et al. 1992. Circ. Res.71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol.183, 2110.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300
• Zwroty wskazujące środki ostrożności: P264 - P270 - P301 + P310 - P405 - P501
• Klasyfikacja zagrożeń: Acute Tox. 2 Oral
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable