344280

Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM).

• Synonim(y): Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem, FST, Phosphotrienin
• Wzór empiryczny (zapis Hilla): C₁₉H₂₆NaO₉P
• Numer CAS: 87860-39-7
• Masa cząsteczkowa: 452.37
• Numer MDL: MFCD09971059
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated (hygroscopic); protect from light
• kolor: colorless
• rozpuszczalność: ethanol: 10 mg/mL; methanol: 10 mg/mL; water: 50 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: −20°C

Opis

Opis ogólny

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC₅₀ = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G₂/M phase of the cell cycle in a dose-dependent manner.

Antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Also inhibits protein phosphatase 1 (PP1) at higher concentrations (IC₅₀ = 131 µM), but has no effect on protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
PP2a

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 3.2 nM, 131 µM, against protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1), respectively

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Inne uwagi

Cheng, A., et al. 1998. Cancer Res. 58, 3611.
Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable