23-043-M

Kit Protein, 10 µg

• Synonim(y): CD_antigen=CD117, Mast/stem cell growth factor receptor, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit
• Kod UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• Poziom jakości: 300
• producent / nazwa handlowa: Upstate^®
• metody: activity assay: suitable
• numer dostępu NCBI: X06182

Opis

Opis ogólny

AXIS Axon Isolation Devices, 150 μm long channels, 10 devices

Kit belongs to the family of type III receptor tyrosine kinases. It mediates the cellular response to stem cell factor and plays a major role in survival, expansion and differentiation of haematopoietic progenitor cells and reproductive stem cells. The activation of Kit is tightly regulated and uncontrolled Kit activity contributes to the growth of diverse human tumours. Gain-of-function mutations have been described in a number of malignancies, including acute myeloid leukaemia, small cell lung cancer, gastrointestinal stromal tumours and testicular cancer. Negative regulation of Kit signalling has been shown to occur mainly through ubiquitin-mediated internalization and degradation of the receptor.

Zastosowanie

Recombinant human Kit, amino acids 544-end. N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

Ubiquitination Cascade Comoponent:Substrate

Postać fizyczna

Format: Purified using glutathione sepharose.

Inne uwagi

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informacje prawne

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H317
• Zwroty wskazujące środki ostrożności: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Klasyfikacja zagrożeń: Skin Sens. 1
• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable