219399

Cathepsin D Substrate I

Useful as a substrate for the determination of cathepsin D activity.

• Synonim(y): Cathepsin D Substrate I, Bz-RGFFP-4-MeOβNA, HCl
• Wzór empiryczny (zapis Hilla): C₄₉H₅₅N₉O₇ · xHCl
• Masa cząsteczkowa: 882.02 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 51111800
• Assay: ≥95% (HPLC)
• Form: lyophilized solid
• Storage condition: OK to freeze, desiccated, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated, protect from light
• color: white
• solubility: DMSO: 5 mg/mL
• fluorescence: λ_ex ~345 nm, λ_em ~425 nm
• shipped in: ambient
• storage temp.: −20°C

Opis

General description

A useful substrate for colorimetric or fluorometric assay of cathepsin D activity. Cathepsin D hydrolyzes the Phe-Phe bond. Dipeptidyl aminopeptidase II is required to free the 4-methoxy-β-naphthylamine (4MβNA). Excitation max: ~345 nm; emission max: ~425 nm.

Useful as a substrate for the determination of cathepsin D activity. Suitable for either colorimetric or fluorometric assay. Cathepsin D hydrolyzes the Phe-Phe bond. Requires dipeptidyl aminopeptidase II to free 4-methoxy-β-naphthylamine (4MeOβNA).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Substrate for the determination of cathepsin D activity

Product does not compete with ATP.

Reversible: no

Other Notes

Bz-Arg-Gly-Phe-Phe-Pro-4MeOβNA, HCl

Takahashi, T., and Tang, J. 1981. Methods Enzymol.80, 565.
Smith, R.E., and Van Frank, R.M. 1975. in Lysosomes in Biology and Pathology4 (Dingle, J.T., and Dean, R.T., eds.) p. 193, American Elsevier, Holland.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable